Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 31% ± 11% | |
astrocyte | 19 studies | 43% ± 21% | |
macrophage | 13 studies | 41% ± 17% | |
oligodendrocyte | 12 studies | 33% ± 12% | |
microglial cell | 12 studies | 37% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 32% ± 16% | |
fibroblast | 10 studies | 33% ± 8% | |
GABAergic neuron | 9 studies | 42% ± 24% | |
glutamatergic neuron | 9 studies | 46% ± 28% | |
adipocyte | 9 studies | 35% ± 12% | |
pericyte | 8 studies | 25% ± 6% | |
myeloid cell | 8 studies | 33% ± 13% | |
basal cell | 8 studies | 35% ± 16% | |
smooth muscle cell | 8 studies | 27% ± 7% | |
epithelial cell | 7 studies | 44% ± 22% | |
ciliated cell | 7 studies | 31% ± 10% | |
endothelial cell of lymphatic vessel | 7 studies | 37% ± 8% | |
neuron | 6 studies | 41% ± 19% | |
interneuron | 6 studies | 44% ± 25% | |
club cell | 6 studies | 38% ± 17% | |
retinal cone cell | 6 studies | 29% ± 6% | |
retinal rod cell | 6 studies | 29% ± 10% | |
Mueller cell | 6 studies | 44% ± 12% | |
type I pneumocyte | 6 studies | 43% ± 15% | |
retina horizontal cell | 5 studies | 32% ± 12% | |
cardiac muscle cell | 5 studies | 32% ± 10% | |
dendritic cell | 5 studies | 27% ± 3% | |
monocyte | 5 studies | 48% ± 8% | |
type II pneumocyte | 5 studies | 33% ± 9% | |
squamous epithelial cell | 4 studies | 51% ± 13% | |
classical monocyte | 4 studies | 23% ± 4% | |
non-classical monocyte | 4 studies | 22% ± 5% | |
granule cell | 4 studies | 24% ± 5% | |
mast cell | 4 studies | 27% ± 11% | |
amacrine cell | 4 studies | 22% ± 6% | |
respiratory goblet cell | 4 studies | 46% ± 20% | |
hematopoietic precursor cell | 3 studies | 36% ± 23% | |
GABAergic interneuron | 3 studies | 28% ± 7% | |
glial cell | 3 studies | 21% ± 5% | |
mononuclear phagocyte | 3 studies | 30% ± 12% | |
vein endothelial cell | 3 studies | 29% ± 14% | |
GABAergic amacrine cell | 3 studies | 21% ± 5% | |
glycinergic amacrine cell | 3 studies | 20% ± 1% | |
endothelial cell of vascular tree | 3 studies | 28% ± 11% | |
cholangiocyte | 3 studies | 51% ± 15% | |
hepatocyte | 3 studies | 54% ± 26% | |
retinal pigment epithelial cell | 3 studies | 44% ± 20% | |
connective tissue cell | 3 studies | 23% ± 8% | |
ependymal cell | 3 studies | 57% ± 23% | |
B cell | 3 studies | 29% ± 6% | |
T cell | 3 studies | 26% ± 5% | |
alveolar macrophage | 3 studies | 53% ± 15% | |
chondrocyte | 3 studies | 28% ± 11% | |
natural killer cell | 3 studies | 24% ± 5% | |
lymphocyte | 3 studies | 27% ± 3% | |
muscle cell | 3 studies | 42% ± 25% | |
goblet cell | 3 studies | 40% ± 32% | |
mucus secreting cell | 3 studies | 46% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2504.81 | 1444 / 1445 | 99% | 15.73 | 182 / 183 |
lung | 100% | 1992.66 | 576 / 578 | 99% | 13.04 | 1140 / 1155 |
intestine | 100% | 1493.35 | 966 / 966 | 98% | 10.82 | 518 / 527 |
stomach | 99% | 1211.86 | 355 / 359 | 97% | 11.64 | 277 / 286 |
brain | 98% | 1337.30 | 2582 / 2642 | 96% | 11.83 | 680 / 705 |
bladder | 100% | 2078.81 | 21 / 21 | 94% | 12.25 | 472 / 504 |
thymus | 100% | 3598.50 | 653 / 653 | 94% | 19.74 | 566 / 605 |
breast | 100% | 1730.32 | 459 / 459 | 91% | 10.11 | 1022 / 1118 |
prostate | 100% | 1722.32 | 245 / 245 | 90% | 13.85 | 451 / 502 |
pancreas | 96% | 827.60 | 316 / 328 | 93% | 11.27 | 166 / 178 |
ovary | 100% | 1939.48 | 180 / 180 | 89% | 8.71 | 382 / 430 |
skin | 100% | 1658.80 | 1806 / 1809 | 85% | 6.67 | 401 / 472 |
kidney | 100% | 1323.70 | 89 / 89 | 83% | 6.61 | 747 / 901 |
uterus | 100% | 1541.65 | 170 / 170 | 83% | 9.78 | 380 / 459 |
adrenal gland | 99% | 1686.43 | 255 / 258 | 75% | 5.83 | 173 / 230 |
liver | 89% | 667.00 | 202 / 226 | 52% | 3.06 | 211 / 406 |
adipose | 100% | 1613.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 1612.43 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.26 | 1 / 1 |
blood vessel | 100% | 2315.26 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2293.30 | 802 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 2070.46 | 901 / 929 | 0% | 0 | 0 / 0 |
heart | 92% | 987.48 | 792 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 9.93 | 37 / 45 |
eye | 0% | 0 | 0 / 0 | 81% | 8.14 | 65 / 80 |
lymph node | 0% | 0 | 0 / 0 | 55% | 6.17 | 16 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0046037 | Biological process | GMP metabolic process |
GO_0006204 | Biological process | IMP catabolic process |
GO_0000255 | Biological process | allantoin metabolic process |
GO_0046085 | Biological process | adenosine metabolic process |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0046054 | Biological process | dGMP metabolic process |
GO_0046040 | Biological process | IMP metabolic process |
GO_0050689 | Biological process | negative regulation of defense response to virus by host |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0050484 | Molecular function | GMP 5'-nucleotidase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0050483 | Molecular function | IMP 5'-nucleotidase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0106411 | Molecular function | XMP 5'-nucleosidase activity |
GO_0050146 | Molecular function | nucleoside phosphotransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008253 | Molecular function | 5'-nucleotidase activity |
Gene name | NT5C2 |
Protein name | 5'-nucleotidase, cytosolic II Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) Cytosolic purine 5'-nucleotidase (EC 2.7.1.77) (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic nucleoside phosphotransferase 5'N) |
Synonyms | NT5CP PNT5 NT5B |
Description | FUNCTION: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates . In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine . Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP . Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency . Through these activities regulates the purine nucleoside/nucleotide pools within the cell . . |
Accessions | ENST00000674728.1 ENST00000675164.1 ENST00000675985.1 [P49902-2] Q5JUV6 ENST00000675645.1 ENST00000552185.5 P49902 ENST00000675811.1 S4R3A6 ENST00000421281.1 ENST00000674860.1 ENST00000675020.1 ENST00000470299.2 ENST00000675436.1 ENST00000343289.9 [P49902-1] ENST00000675040.1 A0A6Q8PF50 ENST00000674696.1 [P49902-1] ENST00000675326.1 [P49902-1] A0A6Q8PHB5 H0YHR8 A0A6Q8PG36 ENST00000404739.8 [P49902-1] ENST00000676428.1 [P49902-1] ENST00000676449.1 [P49902-1] A0A6Q8PEZ2 ENST00000461461.5 A0A6Q8PFH2 ENST00000369857.9 S4R3E7 A0A6Q8PHP0 |