NPAS4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NPAS4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPAS4 at tissue level.

III. Associated gene sets

GO_0007612Biological processlearning
GO_0007616Biological processlong-term memory
GO_0060079Biological processexcitatory postsynaptic potential
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1904862Biological processinhibitory synapse assembly
GO_0048167Biological processregulation of synaptic plasticity
GO_0030154Biological processcell differentiation
GO_0060080Biological processinhibitory postsynaptic potential
GO_0071386Biological processcellular response to corticosterone stimulus
GO_0035176Biological processsocial behavior
GO_0007614Biological processshort-term memory
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032228Biological processregulation of synaptic transmission, GABAergic
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0044877Molecular functionprotein-containing complex binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNPAS4
Protein nameNeuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10)
SynonymsNXF
PASD10
BHLHE79
DescriptionFUNCTION: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 . Can activate the CME (CNS midline enhancer) element . .

AccessionsENST00000311034.7 [Q8IUM7-1]
Q8IUM7
ENST00000525148.1 [Q8IUM7-3]