NNMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090312Biological processpositive regulation of protein deacetylation
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0006769Biological processnicotinamide metabolic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0031100Biological processanimal organ regeneration
GO_0032259Biological processmethylation
GO_0034356Biological processNAD biosynthesis via nicotinamide riboside salvage pathway
GO_0010243Biological processresponse to organonitrogen compound
GO_0005829Cellular componentcytosol
GO_0030760Molecular functionpyridine N-methyltransferase activity
GO_0008112Molecular functionnicotinamide N-methyltransferase activity

IV. Literature review

[source]
Gene nameNNMT
Protein nameNNMT protein (Nicotinamide N-methyltransferase)
Nicotinamide N-methyltransferase (EC 2.1.1.1)
SynonymshCG_39357
DescriptionFUNCTION: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway . Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 . In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state . Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification . .

AccessionsP40261
ENST00000535401.5
ENST00000299964.4
B0YJ53