NMNAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009435Biological processNAD biosynthetic process
GO_0009165Biological processnucleotide biosynthetic process
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0009611Biological processresponse to wounding
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_1902511Biological processnegative regulation of apoptotic DNA fragmentation
GO_1990966Biological processATP generation from poly-ADP-D-ribose
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000309Molecular functionnicotinamide-nucleotide adenylyltransferase activity
GO_0004515Molecular functionnicotinate-nucleotide adenylyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0140768Molecular functionprotein ADP-ribosyltransferase-substrate adaptor activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNMNAT1
Protein nameNicotinamide nucleotide adenylyltransferase 1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)
SynonymsNMNAT
DescriptionFUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP . Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency . Can use triazofurin monophosphate (TrMP) as substrate . Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) . For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively . Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming . Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) . Protects against axonal degeneration following mechanical or toxic insults (By similarity). .

AccessionsQ9HAN9
ENST00000403197.5
ENST00000462686.1
ENST00000377205.6
ENST00000496751.1
K7EPD7
B1AN62