NMI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0032687Biological processnegative regulation of interferon-alpha production
GO_0045087Biological processinnate immune response
GO_0009615Biological processresponse to virus
GO_0045089Biological processpositive regulation of innate immune response
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_1902524Biological processpositive regulation of protein K48-linked ubiquitination
GO_0045824Biological processnegative regulation of innate immune response
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0002281Biological processmacrophage activation involved in immune response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0005615Cellular componentextracellular space
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNMI
Protein nameN-myc and STAT interactor
N-myc-interactor (Nmi) (N-myc and STAT interactor)
Synonyms
DescriptionFUNCTION: Acts as a signaling pathway regulator involved in innate immune system response . In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis . Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription . In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 . In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 . In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries . Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion . Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines . .

AccessionsC9JW17
ENST00000414946.1
Q13287
ENST00000243346.10