NFE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007599Biological processhemostasis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006337Biological processnucleosome disassembly
GO_0140467Biological processintegrated stress response signaling
GO_0032993Cellular componentprotein-DNA complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0050699Molecular functionWW domain binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFE2
Protein nameNuclear factor (Erythroid-derived 2), 45kDa, isoform CRA_a (cDNA FLJ78141, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein) (cDNA FLJ78153, highly similar to nuclear factor erythroid 2 isoform f=basic leucine zipper protein) (cDNA, FLJ93708, Homo sapiens nuclear factor (erythroid-derived 2), 45kDa (NFE2),mRNA)
Nuclear factor, erythroid 2
Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2)
Alternative protein NFE2
SynonymshCG_37258
DescriptionFUNCTION: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. .

AccessionsENST00000553198.1
ENST00000435572.7
A8K3E0
ENST00000312156.8
L8E770
ENST00000553070.5
F8W1N9
ENST00000540264.2
Q16621