NEO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001764Biological processneuron migration
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0007155Biological processcell adhesion
GO_0050709Biological processnegative regulation of protein secretion
GO_0006879Biological processintracellular iron ion homeostasis
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0048681Biological processnegative regulation of axon regeneration
GO_0007520Biological processmyoblast fusion
GO_0098609Biological processcell-cell adhesion
GO_0007411Biological processaxon guidance
GO_0009306Biological processprotein secretion
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0097708Cellular componentintracellular vesicle
GO_0009986Cellular componentcell surface
GO_0098797Cellular componentplasma membrane protein complex
GO_0044295Cellular componentaxonal growth cone
GO_0038023Molecular functionsignaling receptor activity
GO_0039706Molecular functionco-receptor binding
GO_0045296Molecular functioncadherin binding
GO_0070700Molecular functionBMP receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEO1
Protein nameNeogenin (Immunoglobulin superfamily DCC subclass member 2)
Neogenin 1 (Neogenin homolog 1 variant)
SynonymsIGDCC2
NGN
DescriptionFUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. .

AccessionsENST00000558964.5 [Q92859-4]
ENST00000560262.5 [Q92859-3]
Q59FP8
ENST00000560328.1
Q92859
ENST00000261908.11 [Q92859-1]
ENST00000339362.9 [Q92859-1]