NDEL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060052Biological processneurofilament cytoskeleton organization
GO_0033157Biological processregulation of intracellular protein transport
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007059Biological processchromosome segregation
GO_0008090Biological processretrograde axonal transport
GO_0021955Biological processcentral nervous system neuron axonogenesis
GO_0001833Biological processinner cell mass cell proliferation
GO_1900029Biological processpositive regulation of ruffle assembly
GO_0051642Biological processcentrosome localization
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0007020Biological processmicrotubule nucleation
GO_0007100Biological processmitotic centrosome separation
GO_0140650Biological processradial glia-guided pyramidal neuron migration
GO_0047496Biological processvesicle transport along microtubule
GO_0008286Biological processinsulin receptor signaling pathway
GO_0021799Biological processcerebral cortex radially oriented cell migration
GO_0032418Biological processlysosome localization
GO_0051303Biological processestablishment of chromosome localization
GO_0010975Biological processregulation of neuron projection development
GO_1990138Biological processneuron projection extension
GO_0016477Biological processcell migration
GO_0005874Cellular componentmicrotubule
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0043203Cellular componentaxon hillock
GO_0060053Cellular componentneurofilament cytoskeleton
GO_0005871Cellular componentkinesin complex
GO_0031252Cellular componentcell leading edge
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_1904115Cellular componentaxon cytoplasm
GO_0005819Cellular componentspindle
GO_0048487Molecular functionbeta-tubulin binding
GO_0042802Molecular functionidentical protein binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDEL1
Protein nameNuclear distribution protein nudE-like 1
Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
NudE neurodevelopment protein 1 like 1
SynonymsNUDEL
EOPA
MITAP1
DescriptionFUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). .

AccessionsJ3KRK9
ENST00000582490.5
J3QL31
J3QRD2
ENST00000580012.1
A6NIZ0
J3QSD2
ENST00000584866.1
J3KSF2
ENST00000334527.12 [Q9GZM8-1]
Q9GZM8
ENST00000402554.7 [Q9GZM8-3]
J3KT16
ENST00000582665.5
ENST00000581679.1
ENST00000380025.8
ENST00000580237.5
J3QRZ1
ENST00000582277.5
ENST00000582812.5
ENST00000585098.5
J3QL85
J3QLD0