NANS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	25 studies	25% ± 9%	Explore
ciliated cell	16 studies	39% ± 15%	Explore
non-classical monocyte	15 studies	25% ± 11%	Explore
plasma cell	13 studies	39% ± 17%	Explore
classical monocyte	13 studies	24% ± 9%	Explore
conventional dendritic cell	12 studies	28% ± 12%	Explore
goblet cell	11 studies	42% ± 10%	Explore
epithelial cell	10 studies	40% ± 18%	Explore
endothelial cell	10 studies	27% ± 9%	Explore
plasmacytoid dendritic cell	10 studies	25% ± 9%	Explore
plasmablast	8 studies	44% ± 20%	Explore
secretory cell	8 studies	32% ± 12%	Explore
myeloid cell	8 studies	29% ± 11%	Explore
endothelial cell of vascular tree	8 studies	28% ± 6%	Explore
club cell	7 studies	30% ± 9%	Explore
basal cell	7 studies	34% ± 18%	Explore
dendritic cell	7 studies	33% ± 17%	Explore
fibroblast	7 studies	24% ± 8%	Explore
monocyte	6 studies	23% ± 5%	Explore
respiratory goblet cell	6 studies	37% ± 21%	Explore
CD4-positive, alpha-beta T cell	6 studies	17% ± 2%	Explore
alveolar macrophage	5 studies	19% ± 2%	Explore
B cell	5 studies	24% ± 7%	Explore
mononuclear phagocyte	5 studies	24% ± 11%	Explore
transit amplifying cell	5 studies	29% ± 7%	Explore
deuterosomal cell	4 studies	26% ± 7%	Explore
duct epithelial cell	4 studies	35% ± 9%	Explore
smooth muscle cell	4 studies	21% ± 4%	Explore
mucus secreting cell	4 studies	50% ± 31%	Explore
intestinal crypt stem cell	4 studies	24% ± 9%	Explore
IgA plasma cell	4 studies	22% ± 4%	Explore
IgG plasma cell	4 studies	20% ± 5%	Explore
regulatory T cell	4 studies	20% ± 2%	Explore
vein endothelial cell	4 studies	22% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 9%	Explore
pericyte	4 studies	18% ± 3%	Explore
connective tissue cell	4 studies	19% ± 4%	Explore
squamous epithelial cell	3 studies	38% ± 25%	Explore
hematopoietic precursor cell	3 studies	33% ± 4%	Explore
progenitor cell	3 studies	29% ± 13%	Explore
common myeloid progenitor	3 studies	26% ± 8%	Explore
serous secreting cell	3 studies	48% ± 23%	Explore
germinal center B cell	3 studies	31% ± 6%	Explore
intermediate monocyte	3 studies	30% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 2%	Explore
glutamatergic neuron	3 studies	24% ± 3%	Explore
leukocyte	3 studies	28% ± 6%	Explore
T cell	3 studies	17% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	27% ± 13%	Explore
intestine	8 studies	22% ± 6%	Explore
prostate	4 studies	22% ± 5%	Explore
brain	4 studies	19% ± 2%	Explore
pancreas	3 studies	22% ± 2%	Explore
peripheral blood	3 studies	22% ± 2%	Explore
placenta	3 studies	18% ± 2%	Explore
breast	3 studies	17% ± 2%	Explore
liver	3 studies	25% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	4406.16	245 / 245	100%	85.83	502 / 502
esophagus	100%	1270.49	1444 / 1445	100%	19.27	183 / 183
breast	100%	1510.16	459 / 459	100%	33.55	1117 / 1118
lung	100%	1904.79	578 / 578	100%	21.26	1153 / 1155
intestine	100%	3144.75	966 / 966	100%	41.03	526 / 527
uterus	100%	1210.92	170 / 170	100%	26.23	458 / 459
stomach	100%	2119.50	359 / 359	100%	34.03	285 / 286
skin	100%	1588.09	1807 / 1809	100%	27.67	470 / 472
pancreas	100%	1415.78	328 / 328	99%	23.40	177 / 178
ovary	100%	1016.39	180 / 180	99%	14.65	426 / 430
thymus	100%	1179.04	652 / 653	98%	14.76	595 / 605
bladder	100%	1268.10	21 / 21	98%	26.04	492 / 504
adrenal gland	100%	1048.57	258 / 258	96%	16.74	220 / 230
brain	97%	790.91	2566 / 2642	98%	13.10	692 / 705
liver	100%	1459.36	226 / 226	95%	12.66	386 / 406
kidney	100%	1138.37	89 / 89	95%	12.55	855 / 901
adipose	100%	1396.99	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	37.70	29 / 29
spleen	100%	2251.02	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.06	45 / 45
ureter	0%	0	0 / 0	100%	23.27	1 / 1
blood vessel	100%	1259.43	1331 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	26.79	79 / 80
peripheral blood	98%	1587.94	915 / 929	0%	0	0 / 0
muscle	95%	747.85	765 / 803	0%	0	0 / 0
heart	95%	1017.72	817 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006055	Biological process	CMP-N-acetylneuraminate biosynthetic process
GO_0016051	Biological process	carbohydrate biosynthetic process
GO_0070085	Biological process	glycosylation
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0008781	Molecular function	N-acylneuraminate cytidylyltransferase activity
GO_0050462	Molecular function	N-acetylneuraminate synthase activity
GO_0047444	Molecular function	N-acylneuraminate-9-phosphate synthase activity

IV. Literature review

[source]

Gene name	NANS
Protein name	N-acetylneuraminate synthase Sialic acid synthase (N-acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminate-9-phosphate synthase) (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase)
Synonyms	SAS
Description	FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) . Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively . .
Accessions	Q5TBR0 Q9NR45 ENST00000427646.1 ENST00000415280.1 ENST00000210444.6 Q5TBR1

NANS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review