MYO9B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032011Biological processARF protein signal transduction
GO_0072673Biological processlamellipodium morphogenesis
GO_0030048Biological processactin filament-based movement
GO_0035385Biological processRoundabout signaling pathway
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0007266Biological processRho protein signal transduction
GO_0001726Cellular componentruffle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005884Cellular componentactin filament
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0098871Cellular componentpostsynaptic actin cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0016459Cellular componentmyosin complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0043531Molecular functionADP binding
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0048495Molecular functionRoundabout binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMYO9B
Protein nameMYO9B variant protein
MYO9B protein
Unconventional myosin-IXb (Unconventional myosin-9b)
Myosin IXB
SynonymsMYR5
protein
variant
DescriptionFUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions . Also acts as a GTPase activator for RHOA . Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA . .

AccessionsM0QZY4
ENST00000595618.5 [Q13459-2]
ENST00000597073.5
M0R240
ENST00000596942.5
Q4LE74
ENST00000602177.1
M0R0P8
ENST00000682292.1 [Q13459-1]
M0R2J3
ENST00000594971.5
M0R300
ENST00000598419.1
Q8WVD2
M0QXP0
ENST00000594824.5
M0QXX1
ENST00000397274.6 [Q13459-2]
ENST00000602158.1
ENST00000595641.5
M0R332
Q13459