MYO1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900078Biological processpositive regulation of cellular response to insulin stimulus
GO_0006897Biological processendocytosis
GO_0030048Biological processactin filament-based movement
GO_0030050Biological processvesicle transport along actin filament
GO_0006612Biological processprotein targeting to membrane
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0007015Biological processactin filament organization
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0071346Biological processcellular response to type II interferon
GO_0032587Cellular componentruffle membrane
GO_0005903Cellular componentbrush border
GO_0005902Cellular componentmicrovillus
GO_0005730Cellular componentnucleolus
GO_0031941Cellular componentfilamentous actin
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0060171Cellular componentstereocilium membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0016461Cellular componentunconventional myosin complex
GO_0009925Cellular componentbasal plasma membrane
GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005938Cellular componentcell cortex
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0051015Molecular functionactin filament binding
GO_0005102Molecular functionsignaling receptor binding
GO_0031267Molecular functionsmall GTPase binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYO1C
Protein nameMYO1C protein
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Myosin IC
Synonyms
DescriptionFUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. .; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. .

AccessionsENST00000648651.1 [O00159-1]
ENST00000570490.5
ENST00000575335.5
I3L2C3
I3L3Y6
ENST00000575158.5 [O00159-2]
ENST00000570984.7 [O00159-2]
A1L180
O00159
ENST00000648446.1 [O00159-3]
I3L501
ENST00000573853.5
ENST00000545534.6
ENST00000361007.7 [O00159-2]
F5H6E2
ENST00000575011.1
I3L3F5
ENST00000646049.1 [O00159-2]