MTM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0000045Biological processautophagosome assembly
GO_0031929Biological processTOR signaling
GO_0032007Biological processnegative regulation of TOR signaling
GO_0048311Biological processmitochondrion distribution
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0045109Biological processintermediate filament organization
GO_0007005Biological processmitochondrion organization
GO_0048633Biological processpositive regulation of skeletal muscle tissue growth
GO_0008333Biological processendosome to lysosome transport
GO_1902902Biological processnegative regulation of autophagosome assembly
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0015031Biological processprotein transport
GO_0044088Biological processregulation of vacuole organization
GO_0048630Biological processskeletal muscle tissue growth
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0001726Cellular componentruffle
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030175Cellular componentfilopodium
GO_0031674Cellular componentI band
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0004438Molecular functionphosphatidylinositol-3-phosphate phosphatase activity
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0035091Molecular functionphosphatidylinositol binding
GO_0019215Molecular functionintermediate filament binding
GO_0052629Molecular functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTM1
Protein namephosphatidylinositol-3-phosphatase (EC 3.1.3.64) (Phosphatidylinositol-3-phosphate phosphatase)
Myotubularin 1
Myotubularin (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Myotubularin (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)
SynonymsCG2
DescriptionFUNCTION: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture . Plays a role in mitochondrial morphology and positioning . Required for skeletal muscle maintenance but not for myogenesis . In skeletal muscles, stabilizes MTMR12 protein levels . .

AccessionsA0A8I5KYA6
A0A8I5KVR9
A0A8I5KZ76
ENST00000688403.1
ENST00000691851.1
A0A8I5KZ85
ENST00000689694.1 [Q13496-1]
A0A8I5KRS4
ENST00000692915.1
A0A8I5KQR6
ENST00000691232.1
A0A8I5KVB1
ENST00000685944.1 [Q13496-1]
ENST00000689810.1
ENST00000685439.1
ENST00000687215.1
ENST00000692638.1
A0A8I5KW93
Q13496
ENST00000370396.7 [Q13496-1]
ENST00000684910.1
ENST00000691686.1
A0A8I5KT87
A0A8I5QJV9
ENST00000692852.1
A0A8I5QJL1
A0A8I5KNI6
A0A8I5KYJ1
ENST00000692015.1
ENST00000690351.1
ENST00000688152.1
ENST00000689314.1
ENST00000690282.1
B7Z499