MTCH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055088Biological processlipid homeostasis
GO_0010635Biological processregulation of mitochondrial fusion
GO_0070585Biological processprotein localization to mitochondrion
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045040Biological processprotein insertion into mitochondrial outer membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTCH2
Protein nameMitochondrial carrier 2
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
SynonymsMIMP
HSPC032
DescriptionFUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane . Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins . Does not mediate insertion of beta-barrel transmembrane proteins . Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). .

AccessionsQ9Y6C9
ENST00000302503.8
E9PIE4
ENST00000643223.2
ENST00000530428.2