Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 31 studies | 30% ± 13% | |
| smooth muscle cell | 30 studies | 44% ± 16% | |
| endothelial cell | 24 studies | 29% ± 11% | |
| fibroblast | 18 studies | 28% ± 10% | |
| endothelial cell of lymphatic vessel | 14 studies | 38% ± 16% | |
| myofibroblast cell | 10 studies | 35% ± 14% | |
| endothelial cell of artery | 9 studies | 21% ± 3% | |
| vein endothelial cell | 8 studies | 27% ± 14% | |
| adipocyte | 8 studies | 33% ± 8% | |
| astrocyte | 7 studies | 39% ± 19% | |
| cardiac muscle cell | 6 studies | 57% ± 20% | |
| connective tissue cell | 5 studies | 29% ± 7% | |
| capillary endothelial cell | 5 studies | 21% ± 7% | |
| endothelial cell of vascular tree | 5 studies | 34% ± 16% | |
| hematopoietic stem cell | 4 studies | 39% ± 16% | |
| mesothelial cell | 4 studies | 31% ± 9% | |
| Mueller cell | 4 studies | 26% ± 8% | |
| muscle cell | 4 studies | 52% ± 23% | |
| GABAergic neuron | 4 studies | 42% ± 15% | |
| glutamatergic neuron | 4 studies | 44% ± 16% | |
| myoepithelial cell | 4 studies | 44% ± 22% | |
| hepatic stellate cell | 3 studies | 31% ± 11% | |
| retina horizontal cell | 3 studies | 23% ± 7% | |
| type I pneumocyte | 3 studies | 17% ± 1% | |
| interneuron | 3 studies | 43% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 5499.96 | 454 / 459 | 95% | 20.05 | 1058 / 1118 |
| prostate | 92% | 7768.45 | 226 / 245 | 97% | 26.82 | 487 / 502 |
| lung | 98% | 6136.90 | 568 / 578 | 87% | 12.11 | 1008 / 1155 |
| bladder | 95% | 12454.71 | 20 / 21 | 69% | 9.63 | 346 / 504 |
| thymus | 78% | 2848.61 | 511 / 653 | 83% | 8.30 | 500 / 605 |
| esophagus | 79% | 13313.02 | 1140 / 1445 | 79% | 12.06 | 144 / 183 |
| uterus | 98% | 13536.79 | 166 / 170 | 59% | 13.69 | 272 / 459 |
| intestine | 81% | 13582.15 | 778 / 966 | 71% | 8.87 | 374 / 527 |
| skin | 49% | 3025.59 | 887 / 1809 | 85% | 14.36 | 402 / 472 |
| stomach | 52% | 6231.01 | 187 / 359 | 77% | 13.23 | 221 / 286 |
| ovary | 59% | 2718.11 | 106 / 180 | 65% | 5.64 | 279 / 430 |
| brain | 19% | 514.49 | 512 / 2642 | 96% | 9.84 | 679 / 705 |
| kidney | 29% | 935.99 | 26 / 89 | 82% | 15.10 | 738 / 901 |
| blood vessel | 100% | 27426.19 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 6629.41 | 1198 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 98% | 5398.28 | 785 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 22.04 | 3 / 328 | 93% | 21.94 | 166 / 178 |
| heart | 93% | 7138.53 | 797 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 6% | 166.05 | 15 / 258 | 87% | 14.10 | 199 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 3.70 | 23 / 45 |
| liver | 0% | 10.88 | 1 / 226 | 38% | 3.39 | 153 / 406 |
| spleen | 37% | 1195.28 | 89 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 1.10 | 7 / 29 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.36 | 5 / 80 |
| peripheral blood | 0% | 4.85 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030091 | Biological process | protein repair |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0033743 | Molecular function | peptide-methionine (R)-S-oxide reductase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0033745 | Molecular function | L-methionine-(R)-S-oxide reductase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | MSRB3 |
| Protein name | Methionine sulfoxide reductase B3 Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14) Peptide-methionine (R)-S-oxide reductase (EC 1.8.4.12) |
| Synonyms | UNQ1965/PRO4487 |
| Description | FUNCTION: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. . FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. . FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. . FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. . FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. . |
| Accessions | ENST00000540804.5 ENST00000642411.1 [Q8IXL7-2] F5H199 ENST00000541897.5 H7C2B7 F5H4C9 ENST00000535664.5 [Q8IXL7-2] ENST00000535239.5 ENST00000614640.4 [Q8IXL7-2] ENST00000355192.8 [Q8IXL7-1] ENST00000642404.1 [Q8IXL7-2] F5H7C4 Q8IXL7 F5H6G9 ENST00000541189.5 ENST00000647481.1 ENST00000308259.10 [Q8IXL7-2] A0A2R8Y7J8 ENST00000646299.1 [Q8IXL7-2] ENST00000538045.5 ENST00000446731.2 H0YFW5 |