MPHOSPH10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008380Biological processRNA splicing
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0030490Biological processmaturation of SSU-rRNA
GO_0006396Biological processRNA processing
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0005730Cellular componentnucleolus
GO_0034457Cellular componentMpp10 complex
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMPHOSPH10
Protein nameU3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)
U3 small nucleolar ribonucleoprotein protein MPP10
M-phase phosphoprotein 10
SynonymsMPP10
DescriptionFUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. .

AccessionsENST00000468427.2
ENST00000244230.7
A0A8Q3WK70
U3KQ48
A0A8Q3WKH7
ENST00000694907.2
ENST00000695484.2
O00566
A0A8Q3WKB6
ENST00000498451.3