MLF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006351Biological processDNA-templated transcription
GO_0002318Biological processmyeloid progenitor cell differentiation
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMLF1
Protein nameMyeloid leukemia factor 1 (Myeloid leukemia factor 1, isoform CRA_c)
Myeloid leukemia factor 1 variant 2
Myeloid leukemia factor 1
Myeloid leukemia factor 1 isoform 5
Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1)
Myeloid leukemia factor 1 isoform 1 (Myeloid leukemia factor 1, isoform CRA_a)
SynonymshCG_16019
DescriptionFUNCTION: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. .

AccessionsENST00000469452.5 [P58340-2]
A0A0S2Z4U8
ENST00000650753.1
A0A494C1S3
A0A494C1P6
F8WEY0
ENST00000618075.4 [P58340-2]
ENST00000650750.1
A0A494C175
ENST00000487838.5
ENST00000359117.9 [P58340-5]
A0A0S2Z4B4
ENST00000651874.1 [P58340-5]
C9JNE5
ENST00000651984.1 [P58340-5]
ENST00000466246.7
A0A499FJ64
ENST00000478894.7 [P58340-4]
ENST00000495452.5
A0A494C127
ENST00000652045.1
ENST00000482628.5 [P58340-5]
ENST00000619577.5
P58340
C9K0D4
ENST00000651984.1
ENST00000477042.6 [P58340-4]
ENST00000498592.6
ENST00000484955.5 [P58340-5]
A0A0S2Z4A4
ENST00000471745.5 [P58340-4]
F8VXT4
ENST00000355893.11 [P58340-1]
ENST00000491767.6
Q2TLE4