Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 13 studies | 39% ± 16% | |
astrocyte | 13 studies | 31% ± 15% | |
fibroblast | 13 studies | 27% ± 9% | |
glutamatergic neuron | 12 studies | 54% ± 24% | |
GABAergic neuron | 11 studies | 49% ± 24% | |
macrophage | 11 studies | 32% ± 10% | |
oligodendrocyte | 11 studies | 32% ± 13% | |
microglial cell | 10 studies | 29% ± 11% | |
ciliated cell | 10 studies | 32% ± 15% | |
adipocyte | 9 studies | 26% ± 5% | |
epithelial cell | 8 studies | 35% ± 18% | |
classical monocyte | 7 studies | 23% ± 8% | |
type I pneumocyte | 7 studies | 34% ± 11% | |
neuron | 6 studies | 43% ± 14% | |
interneuron | 6 studies | 58% ± 20% | |
retinal ganglion cell | 6 studies | 35% ± 9% | |
myeloid cell | 6 studies | 23% ± 3% | |
Mueller cell | 6 studies | 28% ± 5% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 7% | |
type II pneumocyte | 6 studies | 32% ± 8% | |
smooth muscle cell | 6 studies | 22% ± 3% | |
non-classical monocyte | 5 studies | 23% ± 8% | |
cardiac muscle cell | 5 studies | 27% ± 5% | |
dendritic cell | 5 studies | 21% ± 3% | |
monocyte | 5 studies | 33% ± 7% | |
club cell | 5 studies | 29% ± 11% | |
pericyte | 5 studies | 21% ± 4% | |
basal cell | 5 studies | 34% ± 21% | |
granule cell | 4 studies | 46% ± 12% | |
epithelial cell of proximal tubule | 4 studies | 21% ± 5% | |
platelet | 4 studies | 21% ± 7% | |
amacrine cell | 4 studies | 18% ± 1% | |
lymphocyte | 4 studies | 20% ± 3% | |
retinal rod cell | 4 studies | 20% ± 3% | |
mast cell | 4 studies | 25% ± 4% | |
myofibroblast cell | 4 studies | 25% ± 7% | |
pancreatic A cell | 3 studies | 24% ± 8% | |
hematopoietic precursor cell | 3 studies | 28% ± 14% | |
GABAergic interneuron | 3 studies | 46% ± 6% | |
glial cell | 3 studies | 27% ± 7% | |
retina horizontal cell | 3 studies | 16% ± 1% | |
retinal bipolar neuron | 3 studies | 17% ± 1% | |
GABAergic amacrine cell | 3 studies | 21% ± 4% | |
OFF-bipolar cell | 3 studies | 20% ± 1% | |
ON-bipolar cell | 3 studies | 20% ± 1% | |
glycinergic amacrine cell | 3 studies | 19% ± 0% | |
rod bipolar cell | 3 studies | 20% ± 4% | |
endothelial cell of vascular tree | 3 studies | 24% ± 10% | |
hepatocyte | 3 studies | 60% ± 18% | |
muscle cell | 3 studies | 27% ± 9% | |
connective tissue cell | 3 studies | 21% ± 4% | |
ependymal cell | 3 studies | 26% ± 13% | |
megakaryocyte | 3 studies | 44% ± 13% | |
T cell | 3 studies | 21% ± 6% | |
alveolar macrophage | 3 studies | 39% ± 8% | |
respiratory goblet cell | 3 studies | 34% ± 11% | |
goblet cell | 3 studies | 38% ± 24% | |
mucus secreting cell | 3 studies | 26% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2904.37 | 459 / 459 | 100% | 63.27 | 1118 / 1118 |
esophagus | 100% | 2450.22 | 1445 / 1445 | 100% | 43.25 | 183 / 183 |
intestine | 100% | 2882.65 | 966 / 966 | 100% | 47.07 | 527 / 527 |
kidney | 100% | 3895.20 | 89 / 89 | 100% | 74.16 | 901 / 901 |
lung | 100% | 3099.89 | 578 / 578 | 100% | 52.63 | 1155 / 1155 |
ovary | 100% | 3722.91 | 180 / 180 | 100% | 49.31 | 430 / 430 |
prostate | 100% | 2314.04 | 245 / 245 | 100% | 55.19 | 502 / 502 |
brain | 100% | 4938.55 | 2641 / 2642 | 100% | 72.49 | 705 / 705 |
uterus | 100% | 3881.22 | 170 / 170 | 100% | 51.09 | 458 / 459 |
liver | 100% | 3176.38 | 226 / 226 | 100% | 56.19 | 405 / 406 |
skin | 100% | 3360.25 | 1808 / 1809 | 100% | 45.17 | 471 / 472 |
stomach | 100% | 2671.15 | 359 / 359 | 100% | 49.33 | 285 / 286 |
thymus | 100% | 2138.29 | 651 / 653 | 100% | 48.77 | 604 / 605 |
bladder | 100% | 3201.76 | 21 / 21 | 99% | 43.64 | 501 / 504 |
adrenal gland | 100% | 6341.92 | 258 / 258 | 99% | 54.60 | 228 / 230 |
pancreas | 95% | 1048.86 | 312 / 328 | 100% | 58.67 | 178 / 178 |
adipose | 100% | 2823.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3138.28 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 42.02 | 29 / 29 |
muscle | 100% | 4545.17 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2717.76 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 39.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 33.96 | 1 / 1 |
peripheral blood | 99% | 3550.36 | 920 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 2524.11 | 836 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 28.40 | 77 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051260 | Biological process | protein homooligomerization |
GO_0051561 | Biological process | positive regulation of mitochondrial calcium ion concentration |
GO_0070509 | Biological process | calcium ion import |
GO_0051560 | Biological process | mitochondrial calcium ion homeostasis |
GO_1903852 | Biological process | positive regulation of cristae formation |
GO_1900069 | Biological process | regulation of cellular hyperosmotic salinity response |
GO_0006851 | Biological process | mitochondrial calcium ion transmembrane transport |
GO_0036444 | Biological process | calcium import into the mitochondrion |
GO_0006952 | Biological process | defense response |
GO_0005739 | Cellular component | mitochondrion |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0005758 | Cellular component | mitochondrial intermembrane space |
GO_1990246 | Cellular component | uniplex complex |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0044284 | Cellular component | mitochondrial crista junction |
GO_0034704 | Cellular component | calcium channel complex |
GO_0061891 | Molecular function | calcium ion sensor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0019855 | Molecular function | calcium channel inhibitor activity |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MICU1 |
Protein name | Calcium uptake protein 1, mitochondrial Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4) |
Synonyms | CALC CBARA1 |
Description | FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake . Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening . Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG . . |
Accessions | A0A286YF11 ENST00000489666.2 ENST00000418483.6 [Q9BPX6-4] ENST00000635239.1 E9PQV6 S4R3D7 ENST00000604238.2 Q9BPX6 ENST00000642044.1 ENST00000603011.5 S4R3W3 ENST00000361114.10 [Q9BPX6-1] ENST00000398763.8 [Q9BPX6-5] S4R3V1 A0A0U1RRK1 ENST00000476605.7 |