MICU1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0051561Biological processpositive regulation of mitochondrial calcium ion concentration
GO_0070509Biological processcalcium ion import
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_1903852Biological processpositive regulation of cristae formation
GO_1900069Biological processregulation of cellular hyperosmotic salinity response
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_0036444Biological processcalcium import into the mitochondrion
GO_0006952Biological processdefense response
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_1990246Cellular componentuniplex complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0044284Cellular componentmitochondrial crista junction
GO_0034704Cellular componentcalcium channel complex
GO_0061891Molecular functioncalcium ion sensor activity
GO_0042802Molecular functionidentical protein binding
GO_0019855Molecular functioncalcium channel inhibitor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMICU1
Protein nameCalcium uptake protein 1, mitochondrial
Calcium uptake protein 1, mitochondrial (Atopy-related autoantigen CALC) (ara CALC) (Calcium-binding atopy-related autoantigen 1) (allergen Hom s 4)
SynonymsCALC
CBARA1
DescriptionFUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains . MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake . Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening . Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG . .

AccessionsA0A286YF11
ENST00000489666.2
ENST00000418483.6 [Q9BPX6-4]
ENST00000635239.1
E9PQV6
S4R3D7
ENST00000604238.2
Q9BPX6
ENST00000642044.1
ENST00000603011.5
S4R3W3
ENST00000361114.10 [Q9BPX6-1]
ENST00000398763.8 [Q9BPX6-5]
S4R3V1
A0A0U1RRK1
ENST00000476605.7