MIB2 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	21 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	26% ± 6%	Explore
epithelial cell	6 studies	23% ± 4%	Explore
plasmacytoid dendritic cell	4 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
glutamatergic neuron	3 studies	35% ± 14%	Explore
basal cell	3 studies	28% ± 12%	Explore
astrocyte	3 studies	17% ± 1%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4493.54	1445 / 1445	100%	24.44	183 / 183
uterus	100%	5685.94	170 / 170	100%	18.47	458 / 459
ovary	100%	7290.58	180 / 180	100%	18.17	429 / 430
thymus	100%	6130.78	653 / 653	100%	18.38	603 / 605
brain	100%	5019.76	2636 / 2642	100%	19.78	703 / 705
prostate	100%	6318.12	245 / 245	99%	14.69	499 / 502
intestine	100%	4708.90	966 / 966	98%	16.33	519 / 527
bladder	100%	5128.76	21 / 21	98%	14.10	496 / 504
adrenal gland	100%	3847.92	258 / 258	98%	12.75	225 / 230
kidney	100%	3915.35	89 / 89	98%	11.53	879 / 901
skin	99%	4298.25	1799 / 1809	98%	13.06	463 / 472
pancreas	100%	2266.70	327 / 328	98%	13.60	174 / 178
stomach	100%	3239.48	359 / 359	97%	15.88	277 / 286
lung	100%	4459.12	576 / 578	97%	13.06	1119 / 1155
liver	100%	2544.65	225 / 226	96%	7.94	389 / 406
breast	100%	3452.38	459 / 459	89%	8.24	992 / 1118
eye	0%	0	0 / 0	100%	25.49	80 / 80
lymph node	0%	0	0 / 0	100%	13.16	29 / 29
muscle	100%	7264.05	803 / 803	0%	0	0 / 0
spleen	100%	5164.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.60	45 / 45
ureter	0%	0	0 / 0	100%	13.48	1 / 1
blood vessel	100%	3715.41	1330 / 1335	0%	0	0 / 0
heart	100%	3867.12	857 / 861	0%	0	0 / 0
adipose	99%	3167.31	1197 / 1204	0%	0	0 / 0
peripheral blood	91%	2093.27	844 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016567	Biological process	protein ubiquitination
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0007219	Biological process	Notch signaling pathway
GO_0010803	Biological process	regulation of tumor necrosis factor-mediated signaling pathway
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005769	Cellular component	early endosome
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0003779	Molecular function	actin binding

Gene name	MIB2
Protein name	MIB E3 ubiquitin protein ligase 2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)
Synonyms	SKD ZZANK1
Description	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. .
Accessions	F2Z2L2 J3QLE0 ENST00000518681.6 [Q96AX9-4] ENST00000378708.5 [Q96AX9-6] ENST00000502470.5 ENST00000504599.6 [Q96AX9-1] ENST00000378708 ENST00000486072.1 J3QR95 Q96AX9 ENST00000518681 D6RED3 ENST00000505820 ENST00000378712.5 [Q96AX9-10] H0YAM8 ENST00000489635.5 D6RAZ0 ENST00000510793.5 ENST00000514234.5 D6RDI1 A0A8C8USR6 ENST00000355826.10 [Q96AX9-1] ENST00000503789.5 ENST00000487053.5 A0A8C8N694 ENST00000514363.1 ENST00000505820.7 [Q96AX9-1] ENST00000504599 E9PD12 D6RE96 ENST00000520777.6 [Q96AX9-3] D6RFJ2 D6RHY5 ENST00000520777 ENST00000506488.5 ENST00000483015.1 ENST00000355826 D6R9Q6

MIB2 report