MIB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0001841Biological processneural tube formation
GO_0006897Biological processendocytosis
GO_0007219Biological processNotch signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0001947Biological processheart looping
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0045807Biological processpositive regulation of endocytosis
GO_0030182Biological processneuron differentiation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0001756Biological processsomitogenesis
GO_0001568Biological processblood vessel development
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMIB1
Protein nameE3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
Alternative protein MIB1
SynonymsDIP1
KIAA1323
ZZANK2
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. .; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. .

AccessionsL8EA82
ENST00000261537.7
Q86YT6