Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 21 studies | 32% ± 14% | |
| astrocyte | 15 studies | 37% ± 18% | |
| oligodendrocyte | 12 studies | 33% ± 13% | |
| oligodendrocyte precursor cell | 12 studies | 41% ± 16% | |
| microglial cell | 12 studies | 27% ± 10% | |
| GABAergic neuron | 11 studies | 42% ± 23% | |
| fibroblast | 11 studies | 29% ± 11% | |
| glutamatergic neuron | 10 studies | 51% ± 24% | |
| adipocyte | 9 studies | 24% ± 7% | |
| neuron | 7 studies | 41% ± 20% | |
| epithelial cell | 7 studies | 33% ± 13% | |
| macrophage | 7 studies | 29% ± 10% | |
| pericyte | 7 studies | 29% ± 13% | |
| ciliated cell | 7 studies | 27% ± 7% | |
| interneuron | 6 studies | 51% ± 20% | |
| basal cell | 6 studies | 27% ± 13% | |
| club cell | 6 studies | 26% ± 7% | |
| cardiac muscle cell | 5 studies | 30% ± 5% | |
| endothelial cell of lymphatic vessel | 5 studies | 28% ± 6% | |
| smooth muscle cell | 5 studies | 24% ± 5% | |
| type I pneumocyte | 5 studies | 30% ± 9% | |
| granule cell | 4 studies | 32% ± 5% | |
| lymphocyte | 4 studies | 22% ± 7% | |
| amacrine cell | 4 studies | 22% ± 6% | |
| mast cell | 4 studies | 20% ± 4% | |
| hepatocyte | 4 studies | 44% ± 14% | |
| type II pneumocyte | 4 studies | 24% ± 5% | |
| GABAergic interneuron | 3 studies | 35% ± 9% | |
| glial cell | 3 studies | 26% ± 10% | |
| progenitor cell | 3 studies | 36% ± 8% | |
| brush cell | 3 studies | 25% ± 7% | |
| endothelial cell of artery | 3 studies | 18% ± 1% | |
| mesothelial cell | 3 studies | 32% ± 8% | |
| GABAergic amacrine cell | 3 studies | 24% ± 4% | |
| glycinergic amacrine cell | 3 studies | 23% ± 4% | |
| natural killer cell | 3 studies | 20% ± 4% | |
| endothelial cell of vascular tree | 3 studies | 27% ± 15% | |
| connective tissue cell | 3 studies | 23% ± 4% | |
| ependymal cell | 3 studies | 46% ± 16% | |
| myofibroblast cell | 3 studies | 30% ± 12% | |
| T cell | 3 studies | 21% ± 3% | |
| monocyte | 3 studies | 20% ± 2% | |
| respiratory goblet cell | 3 studies | 28% ± 12% | |
| goblet cell | 3 studies | 32% ± 15% | |
| podocyte | 3 studies | 53% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3025.47 | 1445 / 1445 | 100% | 32.77 | 183 / 183 |
| brain | 100% | 2860.09 | 2639 / 2642 | 100% | 31.35 | 703 / 705 |
| breast | 100% | 3666.42 | 459 / 459 | 99% | 33.69 | 1108 / 1118 |
| lung | 100% | 3075.61 | 577 / 578 | 99% | 23.95 | 1146 / 1155 |
| prostate | 100% | 3256.56 | 245 / 245 | 98% | 20.92 | 493 / 502 |
| thymus | 100% | 3519.42 | 653 / 653 | 98% | 25.00 | 591 / 605 |
| pancreas | 99% | 1869.06 | 326 / 328 | 97% | 19.60 | 173 / 178 |
| uterus | 100% | 4930.74 | 170 / 170 | 95% | 19.00 | 437 / 459 |
| stomach | 100% | 2539.88 | 359 / 359 | 94% | 16.02 | 270 / 286 |
| bladder | 100% | 3620.38 | 21 / 21 | 93% | 16.58 | 470 / 504 |
| intestine | 100% | 3061.58 | 966 / 966 | 92% | 14.56 | 483 / 527 |
| adrenal gland | 100% | 2046.13 | 258 / 258 | 90% | 15.81 | 207 / 230 |
| skin | 100% | 3390.38 | 1808 / 1809 | 90% | 20.92 | 424 / 472 |
| kidney | 100% | 2167.69 | 89 / 89 | 89% | 15.29 | 804 / 901 |
| ovary | 100% | 4466.53 | 180 / 180 | 82% | 8.85 | 352 / 430 |
| liver | 100% | 1332.77 | 225 / 226 | 78% | 10.56 | 315 / 406 |
| adipose | 100% | 3558.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5235.72 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.81 | 1 / 1 |
| spleen | 100% | 1835.29 | 240 / 241 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1653.11 | 798 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 1612.32 | 823 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 21.42 | 43 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 11.27 | 23 / 29 |
| eye | 0% | 0 | 0 / 0 | 68% | 10.97 | 54 / 80 |
| peripheral blood | 55% | 1495.08 | 512 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0001841 | Biological process | neural tube formation |
| GO_0006897 | Biological process | endocytosis |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0001947 | Biological process | heart looping |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0045807 | Biological process | positive regulation of endocytosis |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0001756 | Biological process | somitogenesis |
| GO_0001568 | Biological process | blood vessel development |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0005813 | Cellular component | centrosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MIB1 |
| Protein name | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) Alternative protein MIB1 |
| Synonyms | DIP1 KIAA1323 ZZANK2 |
| Description | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. .; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. . |
| Accessions | L8EA82 ENST00000261537.7 Q86YT6 |