MGA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001708Biological processcell fate specification
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameMGA
Protein nameMAX dimerization protein MGA
MAX gene-associated protein (MAX dimerization protein 5)
SynonymsKIAA0518
MAD5
DescriptionFUNCTION: Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). .

AccessionsENST00000703843.1
A0A994J4J1
H3BU53
H3BP52
ENST00000570161.6
ENST00000566718.6
Q8IWI9
ENST00000219905.13 [Q8IWI9-4]
A0A8C8P5L8
ENST00000703841.1
A0A994J6L2
A0A994J443
ENST00000564190.1
ENST00000566586.6 [Q8IWI9-3]
ENST00000703842.1