MERTK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050766Biological processpositive regulation of phagocytosis
GO_0007283Biological processspermatogenesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0001779Biological processnatural killer cell differentiation
GO_0051250Biological processnegative regulation of lymphocyte activation
GO_2000107Biological processnegative regulation of leukocyte apoptotic process
GO_0007275Biological processmulticellular organism development
GO_0060041Biological processretina development in camera-type eye
GO_0051649Biological processestablishment of localization in cell
GO_0007267Biological processcell-cell signaling
GO_0030168Biological processplatelet activation
GO_0032940Biological processsecretion by cell
GO_0033674Biological processpositive regulation of kinase activity
GO_0060068Biological processvagina development
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0006909Biological processphagocytosis
GO_0001818Biological processnegative regulation of cytokine production
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0007399Biological processnervous system development
GO_0016477Biological processcell migration
GO_0097350Biological processneutrophil clearance
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005737Cellular componentcytoplasm
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMERTK
Protein nameMER proto-oncogene, tyrosine kinase
receptor protein-tyrosine kinase (EC 2.7.10.1)
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Uncharacterized protein MERTK
SynonymsMER
DescriptionFUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment . Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .

AccessionsE9PHX8
ENST00000409780.5
Q1RMG3
Q53QW0
ENST00000295408.9
H7C3L9
ENST00000449344.2
ENST00000439966.5
Q12866
Q53R53
E9PD22