MCM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0006270Biological processDNA replication initiation
GO_0006260Biological processDNA replication
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0042555Cellular componentMCM complex
GO_0071162Cellular componentCMG complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005524Molecular functionATP binding
GO_0043138Molecular function3'-5' DNA helicase activity
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0017116Molecular functionsingle-stranded DNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0003688Molecular functionDNA replication origin binding

IV. Literature review

[source]
Gene nameMCM5
Protein nameDNA replication licensing factor MCM5 (EC 3.6.4.12)
Minichromosome maintenance complex component 5
DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)
DNA helicase (EC 3.6.4.12)
SynonymshCG_41525
CDC46
DescriptionFUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

AccessionsENST00000216122.9
B1AHB1
F8WFD7
B1AHB2
B1AHB0
ENST00000382011.9
ENST00000451351.5
B1AHA9
P33992
ENST00000416905.1
ENST00000444778.1