Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 15 studies | 22% ± 6% | |
plasmacytoid dendritic cell | 9 studies | 21% ± 4% | |
memory B cell | 9 studies | 23% ± 8% | |
natural killer cell | 7 studies | 36% ± 15% | |
CD8-positive, alpha-beta T cell | 7 studies | 30% ± 12% | |
plasmablast | 5 studies | 43% ± 15% | |
conventional dendritic cell | 5 studies | 30% ± 11% | |
pro-B cell | 5 studies | 29% ± 10% | |
T cell | 5 studies | 27% ± 8% | |
CD4-positive, alpha-beta T cell | 5 studies | 26% ± 9% | |
hematopoietic precursor cell | 4 studies | 38% ± 14% | |
plasma cell | 4 studies | 38% ± 16% | |
dendritic cell | 4 studies | 33% ± 12% | |
naive B cell | 4 studies | 20% ± 5% | |
exhausted T cell | 3 studies | 20% ± 5% | |
non-classical monocyte | 3 studies | 24% ± 6% | |
erythroblast | 3 studies | 55% ± 21% | |
germinal center B cell | 3 studies | 25% ± 8% | |
precursor B cell | 3 studies | 26% ± 6% | |
erythrocyte | 3 studies | 36% ± 15% | |
transit amplifying cell | 3 studies | 32% ± 6% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 43% ± 21% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 3 studies | 20% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 100% | 2728.98 | 1809 / 1809 | 100% | 57.57 | 471 / 472 |
uterus | 100% | 1919.38 | 170 / 170 | 100% | 82.07 | 458 / 459 |
esophagus | 100% | 1777.90 | 1440 / 1445 | 100% | 48.60 | 183 / 183 |
ovary | 100% | 2868.36 | 180 / 180 | 100% | 34.96 | 428 / 430 |
intestine | 100% | 1970.22 | 965 / 966 | 99% | 39.95 | 522 / 527 |
stomach | 99% | 1320.96 | 357 / 359 | 99% | 38.81 | 284 / 286 |
lung | 100% | 1827.54 | 576 / 578 | 99% | 41.85 | 1141 / 1155 |
bladder | 100% | 1468.62 | 21 / 21 | 98% | 44.88 | 494 / 504 |
breast | 100% | 1826.19 | 459 / 459 | 98% | 28.27 | 1092 / 1118 |
thymus | 100% | 1520.53 | 652 / 653 | 97% | 31.22 | 587 / 605 |
prostate | 99% | 1301.44 | 243 / 245 | 94% | 13.92 | 470 / 502 |
pancreas | 96% | 904.36 | 316 / 328 | 96% | 24.72 | 171 / 178 |
kidney | 100% | 1123.16 | 89 / 89 | 90% | 20.20 | 815 / 901 |
brain | 85% | 591.60 | 2245 / 2642 | 95% | 23.64 | 667 / 705 |
liver | 88% | 814.62 | 198 / 226 | 87% | 25.27 | 354 / 406 |
adrenal gland | 96% | 850.06 | 248 / 258 | 47% | 7.77 | 107 / 230 |
adipose | 100% | 1628.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 28.26 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 159.14 | 29 / 29 |
spleen | 100% | 5562.58 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 114.91 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 31.09 | 1 / 1 |
blood vessel | 100% | 1376.06 | 1329 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4413.78 | 919 / 929 | 0% | 0 | 0 / 0 |
muscle | 97% | 844.06 | 778 / 803 | 0% | 0 | 0 / 0 |
heart | 92% | 697.57 | 796 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0000727 | Biological process | double-strand break repair via break-induced replication |
GO_0006268 | Biological process | DNA unwinding involved in DNA replication |
GO_0006270 | Biological process | DNA replication initiation |
GO_0006260 | Biological process | DNA replication |
GO_0030174 | Biological process | regulation of DNA-templated DNA replication initiation |
GO_0042555 | Cellular component | MCM complex |
GO_0071162 | Cellular component | CMG complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005634 | Cellular component | nucleus |
GO_0005524 | Molecular function | ATP binding |
GO_0043138 | Molecular function | 3'-5' DNA helicase activity |
GO_0005515 | Molecular function | protein binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0017116 | Molecular function | single-stranded DNA helicase activity |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0003688 | Molecular function | DNA replication origin binding |
Gene name | MCM5 |
Protein name | DNA replication licensing factor MCM5 (EC 3.6.4.12) Minichromosome maintenance complex component 5 DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) DNA helicase (EC 3.6.4.12) |
Synonyms | hCG_41525 CDC46 |
Description | FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . . FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. . FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. . FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. . |
Accessions | ENST00000216122.9 B1AHB1 F8WFD7 B1AHB2 B1AHB0 ENST00000382011.9 ENST00000451351.5 B1AHA9 P33992 ENST00000416905.1 ENST00000444778.1 |