MARCHF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0002495Biological processantigen processing and presentation of peptide antigen via MHC class II
GO_0000209Biological processprotein polyubiquitination
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005764Cellular componentlysosome
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0031902Cellular componentlate endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0042287Molecular functionMHC protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMARCHF8
Protein nameE3 ubiquitin-protein ligase MARCHF8
E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8)
Membrane associated ring-CH-type finger 8
SynonymsRNF178
MARCH8
MIR
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity . Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies . Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins . Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation . Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses . Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Blocks also ebola virus glycoprotein/GP incorporation via surface down-regulation . Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation . Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway . Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination . Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity . .; FUNCTION: (Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment. .

AccessionsENST00000612386.1
ENST00000453980.3
ENST00000319836.7 [Q5T0T0-1]
A0A0G2JNS9
Q5T0T0
ENST00000395769.6 [Q5T0T0-1]
A0A0A0MSM7
ENST00000453424.7 [Q5T0T0-2]
ENST00000395771.7