LYPLA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
ciliated cell	10 studies	30% ± 11%	Explore
regulatory T cell	10 studies	22% ± 4%	Explore
natural killer cell	8 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	6 studies	19% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	17% ± 2%	Explore
epithelial cell	6 studies	33% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	20% ± 4%	Explore
classical monocyte	5 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
gamma-delta T cell	5 studies	22% ± 8%	Explore
mature NK T cell	4 studies	18% ± 1%	Explore
non-classical monocyte	4 studies	25% ± 6%	Explore
basal cell	4 studies	36% ± 11%	Explore
endothelial cell	4 studies	25% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
goblet cell	4 studies	20% ± 4%	Explore
hematopoietic precursor cell	3 studies	20% ± 3%	Explore
exhausted T cell	3 studies	19% ± 4%	Explore
dendritic cell	3 studies	29% ± 7%	Explore
enteroendocrine cell	3 studies	23% ± 7%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 6%	Explore
mucosal invariant T cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	17% ± 1%	Explore
lung	4 studies	25% ± 12%	Explore
intestine	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2895.82	1445 / 1445	100%	102.98	183 / 183
liver	100%	3115.03	226 / 226	100%	108.27	406 / 406
ovary	100%	1847.32	180 / 180	100%	137.83	430 / 430
thymus	100%	2995.84	653 / 653	100%	172.67	604 / 605
skin	100%	3088.00	1809 / 1809	100%	175.72	471 / 472
uterus	100%	2167.19	170 / 170	100%	173.81	458 / 459
stomach	100%	2628.79	359 / 359	100%	124.24	285 / 286
intestine	100%	2902.59	966 / 966	100%	142.43	525 / 527
kidney	100%	5042.20	89 / 89	100%	103.85	897 / 901
pancreas	100%	1792.38	328 / 328	99%	142.97	177 / 178
prostate	100%	3344.21	245 / 245	99%	145.61	499 / 502
brain	100%	1913.92	2632 / 2642	100%	61.43	702 / 705
breast	100%	2483.04	459 / 459	99%	122.46	1109 / 1118
lung	100%	2930.91	578 / 578	99%	129.25	1143 / 1155
bladder	100%	2684.10	21 / 21	99%	183.86	497 / 504
adrenal gland	100%	2770.64	258 / 258	97%	78.28	222 / 230
adipose	100%	2190.40	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	158.59	80 / 80
lymph node	0%	0	0 / 0	100%	160.41	29 / 29
spleen	100%	4227.62	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	135.88	45 / 45
ureter	0%	0	0 / 0	100%	210.20	1 / 1
blood vessel	100%	1647.27	1332 / 1335	0%	0	0 / 0
muscle	100%	1714.92	799 / 803	0%	0	0 / 0
peripheral blood	99%	3453.20	922 / 929	0%	0	0 / 0
heart	99%	1715.98	854 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046464	Biological process	acylglycerol catabolic process
GO_0006631	Biological process	fatty acid metabolic process
GO_1905344	Biological process	prostaglandin catabolic process
GO_0007411	Biological process	axon guidance
GO_0002084	Biological process	protein depalmitoylation
GO_0005795	Cellular component	Golgi stack
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0045296	Molecular function	cadherin binding
GO_0004622	Molecular function	lysophospholipase activity
GO_0005515	Molecular function	protein binding
GO_0052689	Molecular function	carboxylic ester hydrolase activity
GO_0008474	Molecular function	palmitoyl-(protein) hydrolase activity

IV. Literature review

[source]

Gene name	LYPLA2
Protein name	palmitoyl-protein hydrolase (EC 3.1.2.22) Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)
Synonyms	hCG_1981746 APT2
Description	FUNCTION: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS . Deacylates GAP43 . Mediates depalmitoylation of ZDHHC6 . Has lysophospholipase activity . Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) . Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide . .
Accessions	Q5QPN5 ENST00000374501.1 Q5QPQ3 O95372 Q5QPQ0 Q5QPQ1 ENST00000374502.7 ENST00000420982.5 Q5QPQ2 Q5QPN9 A0A140VJC9 ENST00000374505.6 ENST00000421070.1 ENST00000374514.8 ENST00000374503.7

LYPLA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review