LTC4S report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LTC4S at tissue level.

III. Associated gene sets

GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0019370Biological processleukotriene biosynthetic process
GO_0006691Biological processleukotriene metabolic process
GO_0098869Biological processcellular oxidant detoxification
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005783Cellular componentendoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0005640Cellular componentnuclear outer membrane
GO_0005635Cellular componentnuclear envelope
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008047Molecular functionenzyme activator activity
GO_0004464Molecular functionleukotriene-C4 synthase activity
GO_0004364Molecular functionglutathione transferase activity
GO_0005515Molecular functionprotein binding
GO_0004602Molecular functionglutathione peroxidase activity
GO_0008289Molecular functionlipid binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameLTC4S
Protein nameLeukotriene C4 synthase
Leukotriene C4 synthase (EC 4.4.1.20) (Glutathione S-transferase LTC4) (Leukotriene-C(4) synthase)
Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase)
Synonyms
DescriptionFUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity . Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions . .

AccessionsENST00000486713.1
ENST00000505170.5
ENST00000292596.15
A0A286YF10
ENST00000639087.2
B5MCC3
ENST00000401985.3
Q16873
D6RJA1