Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 22 studies | 57% ± 19% | |
| macrophage | 15 studies | 27% ± 8% | |
| endothelial cell of artery | 9 studies | 32% ± 14% | |
| endothelial cell | 8 studies | 22% ± 5% | |
| endothelial cell of lymphatic vessel | 7 studies | 21% ± 4% | |
| capillary endothelial cell | 6 studies | 22% ± 6% | |
| vein endothelial cell | 5 studies | 36% ± 25% | |
| microglial cell | 4 studies | 31% ± 12% | |
| conventional dendritic cell | 4 studies | 25% ± 8% | |
| endothelial cell of vascular tree | 4 studies | 19% ± 2% | |
| glomerular endothelial cell | 3 studies | 24% ± 5% | |
| dendritic cell | 3 studies | 26% ± 6% | |
| granulocyte | 3 studies | 65% ± 18% | |
| secretory cell | 3 studies | 20% ± 5% |
Insufficient scRNA-seq data for expression of LTC4S at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 0% | 0 | 0 / 0 | 99% | 13.10 | 601 / 605 |
| ovary | 0% | 0 | 0 / 0 | 99% | 27.69 | 427 / 430 |
| brain | 0% | 0 | 0 / 0 | 98% | 12.76 | 693 / 705 |
| prostate | 0% | 0 | 0 / 0 | 98% | 10.65 | 490 / 502 |
| adrenal gland | 0% | 0 | 0 / 0 | 93% | 7.94 | 215 / 230 |
| kidney | 0% | 0 | 0 / 0 | 93% | 10.52 | 836 / 901 |
| pancreas | 0% | 0 | 0 / 0 | 90% | 7.16 | 161 / 178 |
| breast | 0% | 0 | 0 / 0 | 85% | 7.21 | 952 / 1118 |
| esophagus | 0% | 0 | 0 / 0 | 82% | 4.24 | 150 / 183 |
| uterus | 0% | 0 | 0 / 0 | 79% | 4.45 | 361 / 459 |
| lung | 0% | 0 | 0 / 0 | 79% | 4.39 | 907 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 3.88 | 35 / 45 |
| bladder | 0% | 0 | 0 / 0 | 71% | 3.88 | 359 / 504 |
| stomach | 0% | 0 | 0 / 0 | 70% | 4.18 | 201 / 286 |
| liver | 0% | 0 | 0 / 0 | 60% | 3.81 | 242 / 406 |
| intestine | 0% | 0 | 0 / 0 | 58% | 2.92 | 308 / 527 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 2.06 | 15 / 29 |
| eye | 0% | 0 | 0 / 0 | 43% | 1.49 | 34 / 80 |
| skin | 0% | 0 | 0 / 0 | 36% | 1.40 | 168 / 472 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042759 | Biological process | long-chain fatty acid biosynthetic process |
| GO_0019370 | Biological process | leukotriene biosynthetic process |
| GO_0006691 | Biological process | leukotriene metabolic process |
| GO_0098869 | Biological process | cellular oxidant detoxification |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005640 | Cellular component | nuclear outer membrane |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0004464 | Molecular function | leukotriene-C4 synthase activity |
| GO_0004364 | Molecular function | glutathione transferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004602 | Molecular function | glutathione peroxidase activity |
| GO_0008289 | Molecular function | lipid binding |
| GO_0042802 | Molecular function | identical protein binding |
| Gene name | LTC4S |
| Protein name | Leukotriene C4 synthase Leukotriene C4 synthase (EC 4.4.1.20) (Glutathione S-transferase LTC4) (Leukotriene-C(4) synthase) Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity . Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions . . |
| Accessions | ENST00000486713.1 ENST00000505170.5 ENST00000292596.15 A0A286YF10 ENST00000639087.2 B5MCC3 ENST00000401985.3 Q16873 D6RJA1 |