Name | Number of supported studies | Average coverage | |
---|---|---|---|
mast cell | 22 studies | 57% ± 19% | |
macrophage | 15 studies | 27% ± 8% | |
endothelial cell of artery | 9 studies | 32% ± 14% | |
endothelial cell | 8 studies | 22% ± 5% | |
endothelial cell of lymphatic vessel | 7 studies | 21% ± 4% | |
capillary endothelial cell | 6 studies | 22% ± 6% | |
vein endothelial cell | 5 studies | 36% ± 25% | |
microglial cell | 4 studies | 31% ± 12% | |
conventional dendritic cell | 4 studies | 25% ± 8% | |
endothelial cell of vascular tree | 4 studies | 19% ± 2% | |
glomerular endothelial cell | 3 studies | 24% ± 5% | |
dendritic cell | 3 studies | 26% ± 6% | |
granulocyte | 3 studies | 65% ± 18% | |
secretory cell | 3 studies | 20% ± 5% |
Insufficient scRNA-seq data for expression of LTC4S at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 0% | 0 | 0 / 0 | 99% | 13.10 | 601 / 605 |
ovary | 0% | 0 | 0 / 0 | 99% | 27.69 | 427 / 430 |
brain | 0% | 0 | 0 / 0 | 98% | 12.76 | 693 / 705 |
prostate | 0% | 0 | 0 / 0 | 98% | 10.65 | 490 / 502 |
adrenal gland | 0% | 0 | 0 / 0 | 93% | 7.94 | 215 / 230 |
kidney | 0% | 0 | 0 / 0 | 93% | 10.52 | 836 / 901 |
pancreas | 0% | 0 | 0 / 0 | 90% | 7.16 | 161 / 178 |
breast | 0% | 0 | 0 / 0 | 85% | 7.21 | 952 / 1118 |
esophagus | 0% | 0 | 0 / 0 | 82% | 4.24 | 150 / 183 |
uterus | 0% | 0 | 0 / 0 | 79% | 4.45 | 361 / 459 |
lung | 0% | 0 | 0 / 0 | 79% | 4.39 | 907 / 1155 |
tonsil | 0% | 0 | 0 / 0 | 78% | 3.88 | 35 / 45 |
bladder | 0% | 0 | 0 / 0 | 71% | 3.88 | 359 / 504 |
stomach | 0% | 0 | 0 / 0 | 70% | 4.18 | 201 / 286 |
liver | 0% | 0 | 0 / 0 | 60% | 3.81 | 242 / 406 |
intestine | 0% | 0 | 0 / 0 | 58% | 2.92 | 308 / 527 |
lymph node | 0% | 0 | 0 / 0 | 52% | 2.06 | 15 / 29 |
eye | 0% | 0 | 0 / 0 | 43% | 1.49 | 34 / 80 |
skin | 0% | 0 | 0 / 0 | 36% | 1.40 | 168 / 472 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
adipose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
blood vessel | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042759 | Biological process | long-chain fatty acid biosynthetic process |
GO_0019370 | Biological process | leukotriene biosynthetic process |
GO_0006691 | Biological process | leukotriene metabolic process |
GO_0098869 | Biological process | cellular oxidant detoxification |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005640 | Cellular component | nuclear outer membrane |
GO_0005635 | Cellular component | nuclear envelope |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0008047 | Molecular function | enzyme activator activity |
GO_0004464 | Molecular function | leukotriene-C4 synthase activity |
GO_0004364 | Molecular function | glutathione transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004602 | Molecular function | glutathione peroxidase activity |
GO_0008289 | Molecular function | lipid binding |
GO_0042802 | Molecular function | identical protein binding |
Gene name | LTC4S |
Protein name | Leukotriene C4 synthase Leukotriene C4 synthase (EC 4.4.1.20) (Glutathione S-transferase LTC4) (Leukotriene-C(4) synthase) Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Glutathione S-transferase LTC4) (EC 2.5.1.-) (Leukotriene-C(4) synthase) (Leukotriene-C4 synthase) |
Synonyms | |
Description | FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity . Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions . . |
Accessions | ENST00000486713.1 ENST00000505170.5 ENST00000292596.15 A0A286YF10 ENST00000639087.2 B5MCC3 ENST00000401985.3 Q16873 D6RJA1 |