LPL | OmnibusX

Name	Number of supported studies	Average coverage
pericyte	16 studies	40% ± 17%	Explore
adipocyte	10 studies	67% ± 14%	Explore
alveolar macrophage	8 studies	42% ± 18%	Explore
fibroblast	6 studies	27% ± 9%	Explore
macrophage	6 studies	32% ± 15%	Explore
cardiac muscle cell	5 studies	48% ± 16%	Explore
retina horizontal cell	4 studies	41% ± 5%	Explore
type II pneumocyte	4 studies	21% ± 6%	Explore
endothelial cell	4 studies	24% ± 4%	Explore
myeloid cell	4 studies	25% ± 15%	Explore
smooth muscle cell	3 studies	21% ± 2%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
heart	3 studies	30% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	90%	45466.18	411 / 459	75%	35.64	841 / 1118
lung	97%	11006.92	560 / 578	58%	23.84	673 / 1155
brain	32%	2750.54	836 / 2642	99%	203.25	700 / 705
adipose	100%	63638.15	1203 / 1204	0%	0	0 / 0
thymus	14%	725.97	90 / 653	80%	34.74	481 / 605
heart	88%	27652.27	754 / 861	0%	0	0 / 0
muscle	80%	8079.40	644 / 803	0%	0	0 / 0
kidney	8%	621.47	7 / 89	65%	18.92	587 / 901
skin	7%	418.91	129 / 1809	58%	52.31	275 / 472
pancreas	2%	77.02	5 / 328	60%	15.21	107 / 178
adrenal gland	10%	605.28	26 / 258	38%	14.66	88 / 230
intestine	17%	1207.36	167 / 966	31%	6.73	163 / 527
stomach	11%	823.56	38 / 359	33%	6.73	94 / 286
esophagus	17%	891.28	241 / 1445	25%	3.57	46 / 183
bladder	10%	503.52	2 / 21	27%	9.79	136 / 504
ovary	17%	893.13	30 / 180	18%	3.07	79 / 430
eye	0%	0	0 / 0	26%	4.69	21 / 80
tonsil	0%	0	0 / 0	22%	6.35	10 / 45
prostate	4%	241.56	9 / 245	17%	3.48	84 / 502
uterus	0%	0	0 / 170	19%	5.61	85 / 459
blood vessel	16%	2696.99	220 / 1335	0%	0	0 / 0
liver	0%	0	0 / 226	8%	1.43	33 / 406
lymph node	0%	0	0 / 0	7%	1.48	2 / 29
spleen	0%	15.89	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0010744	Biological process	positive regulation of macrophage derived foam cell differentiation
GO_0070328	Biological process	triglyceride homeostasis
GO_1904179	Biological process	positive regulation of adipose tissue development
GO_0032722	Biological process	positive regulation of chemokine production
GO_0010890	Biological process	positive regulation of sequestering of triglyceride
GO_0009749	Biological process	response to glucose
GO_0009617	Biological process	response to bacterium
GO_0034372	Biological process	very-low-density lipoprotein particle remodeling
GO_0010886	Biological process	positive regulation of cholesterol storage
GO_0055096	Biological process	low-density lipoprotein particle mediated signaling
GO_0031670	Biological process	cellular response to nutrient
GO_0006631	Biological process	fatty acid metabolic process
GO_0034375	Biological process	high-density lipoprotein particle remodeling
GO_2000343	Biological process	positive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_0034371	Biological process	chylomicron remodeling
GO_0019433	Biological process	triglyceride catabolic process
GO_0006633	Biological process	fatty acid biosynthetic process
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_0006641	Biological process	triglyceride metabolic process
GO_0006644	Biological process	phospholipid metabolic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0010884	Biological process	positive regulation of lipid storage
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0042632	Biological process	cholesterol homeostasis
GO_0071398	Biological process	cellular response to fatty acid
GO_0042627	Cellular component	chylomicron
GO_0005615	Cellular component	extracellular space
GO_1902494	Cellular component	catalytic complex
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0034361	Cellular component	very-low-density lipoprotein particle
GO_0008201	Molecular function	heparin binding
GO_0004620	Molecular function	phospholipase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0008970	Molecular function	phospholipase A1 activity
GO_0004465	Molecular function	lipoprotein lipase activity
GO_0052739	Molecular function	phosphatidylserine 1-acylhydrolase activity
GO_0043495	Molecular function	protein-membrane adaptor activity
GO_0052740	Molecular function	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO_0004806	Molecular function	triglyceride lipase activity
GO_0071813	Molecular function	lipoprotein particle binding
GO_0005102	Molecular function	signaling receptor binding
GO_0034185	Molecular function	apolipoprotein binding
GO_0043395	Molecular function	heparan sulfate proteoglycan binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LPL
Protein name	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32) Lipoprotein lipase Phospholipase A1 Lipoprotein lipase (LPL) (EC 3.1.1.34)
Synonyms	LIPD lpl
Description	FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. . FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage . Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity . Mediates margination of triglyceride-rich lipoprotein particles in capillaries . Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans . . FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. .
Accessions	A0A1B1RVA9 Q8NEW3 ENST00000650478.1 ENST00000524029.5 A0A6B9JFD6 Q6IAV0 A0A3B3IT60 E5RJZ4 E5RJI0 ENST00000519773.1 P06858 ENST00000650287.1 E5RHN7 E7EW14 ENST00000520959.5 ENST00000522701.5

LPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review