Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 26% ± 11% | |
oligodendrocyte | 15 studies | 63% ± 16% | |
classical monocyte | 11 studies | 26% ± 10% | |
natural killer cell | 10 studies | 20% ± 5% | |
glutamatergic neuron | 10 studies | 38% ± 23% | |
oligodendrocyte precursor cell | 10 studies | 30% ± 10% | |
ciliated cell | 9 studies | 25% ± 7% | |
microglial cell | 9 studies | 23% ± 7% | |
B cell | 8 studies | 22% ± 5% | |
astrocyte | 8 studies | 25% ± 9% | |
adipocyte | 8 studies | 35% ± 10% | |
GABAergic neuron | 8 studies | 44% ± 18% | |
CD16-positive, CD56-dim natural killer cell, human | 7 studies | 22% ± 5% | |
neuron | 7 studies | 37% ± 17% | |
macrophage | 7 studies | 27% ± 8% | |
epithelial cell | 7 studies | 34% ± 11% | |
retinal rod cell | 7 studies | 25% ± 6% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 23% ± 8% | |
amacrine cell | 6 studies | 27% ± 3% | |
interneuron | 6 studies | 45% ± 19% | |
dendritic cell | 6 studies | 28% ± 17% | |
plasmacytoid dendritic cell | 6 studies | 22% ± 5% | |
non-classical monocyte | 5 studies | 22% ± 9% | |
enterocyte | 5 studies | 26% ± 7% | |
retinal bipolar neuron | 5 studies | 50% ± 12% | |
retinal ganglion cell | 5 studies | 30% ± 13% | |
myeloid cell | 5 studies | 24% ± 5% | |
naive B cell | 4 studies | 17% ± 1% | |
granule cell | 4 studies | 20% ± 3% | |
retinal cone cell | 4 studies | 24% ± 1% | |
retinal pigment epithelial cell | 4 studies | 44% ± 8% | |
cardiac muscle cell | 4 studies | 18% ± 1% | |
lymphocyte | 4 studies | 21% ± 7% | |
hepatocyte | 4 studies | 56% ± 23% | |
monocyte | 4 studies | 27% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 20% ± 4% | |
fibroblast | 4 studies | 22% ± 6% | |
pericyte | 4 studies | 17% ± 3% | |
ionocyte | 3 studies | 40% ± 2% | |
pancreatic A cell | 3 studies | 35% ± 9% | |
conventional dendritic cell | 3 studies | 30% ± 9% | |
hematopoietic precursor cell | 3 studies | 35% ± 13% | |
mature NK T cell | 3 studies | 27% ± 8% | |
GABAergic interneuron | 3 studies | 31% ± 3% | |
glial cell | 3 studies | 24% ± 9% | |
GABAergic amacrine cell | 3 studies | 34% ± 12% | |
OFF-bipolar cell | 3 studies | 31% ± 7% | |
ON-bipolar cell | 3 studies | 44% ± 10% | |
glycinergic amacrine cell | 3 studies | 23% ± 3% | |
rod bipolar cell | 3 studies | 85% ± 7% | |
cholangiocyte | 3 studies | 61% ± 13% | |
smooth muscle cell | 3 studies | 16% ± 1% | |
basal cell | 3 studies | 34% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2904.50 | 1444 / 1445 | 100% | 37.38 | 183 / 183 |
breast | 100% | 3759.96 | 459 / 459 | 100% | 54.89 | 1115 / 1118 |
liver | 100% | 7079.49 | 226 / 226 | 100% | 66.10 | 404 / 406 |
thymus | 100% | 7627.68 | 653 / 653 | 100% | 30.76 | 602 / 605 |
lung | 100% | 3369.43 | 577 / 578 | 100% | 36.80 | 1150 / 1155 |
uterus | 100% | 3111.27 | 170 / 170 | 98% | 31.12 | 452 / 459 |
prostate | 100% | 4031.19 | 245 / 245 | 98% | 24.34 | 494 / 502 |
pancreas | 100% | 3035.32 | 327 / 328 | 98% | 35.13 | 175 / 178 |
bladder | 100% | 3187.14 | 21 / 21 | 98% | 28.41 | 492 / 504 |
intestine | 100% | 3598.58 | 966 / 966 | 98% | 32.15 | 514 / 527 |
stomach | 99% | 1863.29 | 354 / 359 | 99% | 32.66 | 282 / 286 |
brain | 100% | 4433.11 | 2635 / 2642 | 97% | 17.41 | 685 / 705 |
kidney | 100% | 3019.20 | 89 / 89 | 96% | 33.10 | 861 / 901 |
adrenal gland | 100% | 6307.16 | 258 / 258 | 94% | 23.07 | 216 / 230 |
skin | 98% | 2430.48 | 1777 / 1809 | 95% | 38.93 | 449 / 472 |
ovary | 100% | 2222.54 | 180 / 180 | 83% | 12.24 | 356 / 430 |
adipose | 100% | 4303.93 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3501.92 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 4685.72 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 22.53 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.63 | 1 / 1 |
muscle | 99% | 1947.23 | 795 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 6434.26 | 911 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 18.60 | 28 / 29 |
heart | 97% | 2306.08 | 831 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 15.71 | 59 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019432 | Biological process | triglyceride biosynthetic process |
GO_0008654 | Biological process | phospholipid biosynthetic process |
GO_0036148 | Biological process | phosphatidylglycerol acyl-chain remodeling |
GO_0036149 | Biological process | phosphatidylinositol acyl-chain remodeling |
GO_0036152 | Biological process | phosphatidylethanolamine acyl-chain remodeling |
GO_0045723 | Biological process | positive regulation of fatty acid biosynthetic process |
GO_0005737 | Cellular component | cytoplasm |
GO_0012505 | Cellular component | endomembrane system |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0047144 | Molecular function | 2-acylglycerol-3-phosphate O-acyltransferase activity |
GO_0003841 | Molecular function | 1-acylglycerol-3-phosphate O-acyltransferase activity |
GO_0003846 | Molecular function | 2-acylglycerol O-acyltransferase activity |
GO_0071617 | Molecular function | lysophospholipid acyltransferase activity |
GO_0016746 | Molecular function | acyltransferase activity |
GO_0047190 | Molecular function | 2-acylglycerophosphocholine O-acyltransferase activity |
GO_0071618 | Molecular function | lysophosphatidylethanolamine acyltransferase activity |
Gene name | LPGAT1 |
Protein name | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) |
Synonyms | KIAA0205 FAM34A |
Description | FUNCTION: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor . Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors . Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). . |
Accessions | ENST00000366997.9 Q92604 ENST00000366996.1 |