LPGAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019432Biological processtriglyceride biosynthetic process
GO_0008654Biological processphospholipid biosynthetic process
GO_0036148Biological processphosphatidylglycerol acyl-chain remodeling
GO_0036149Biological processphosphatidylinositol acyl-chain remodeling
GO_0036152Biological processphosphatidylethanolamine acyl-chain remodeling
GO_0045723Biological processpositive regulation of fatty acid biosynthetic process
GO_0005737Cellular componentcytoplasm
GO_0012505Cellular componentendomembrane system
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0047144Molecular function2-acylglycerol-3-phosphate O-acyltransferase activity
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0003846Molecular function2-acylglycerol O-acyltransferase activity
GO_0071617Molecular functionlysophospholipid acyltransferase activity
GO_0016746Molecular functionacyltransferase activity
GO_0047190Molecular function2-acylglycerophosphocholine O-acyltransferase activity
GO_0071618Molecular functionlysophosphatidylethanolamine acyltransferase activity

IV. Literature review

[source]
Gene nameLPGAT1
Protein nameAcyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase)
SynonymsKIAA0205
FAM34A
DescriptionFUNCTION: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor . Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors . Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). .

AccessionsENST00000366997.9
Q92604
ENST00000366996.1