LIG4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051103Biological processDNA ligation involved in DNA repair
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0000012Biological processsingle strand break repair
GO_0008283Biological processcell population proliferation
GO_0010165Biological processresponse to X-ray
GO_0001701Biological processin utero embryonic development
GO_0075713Biological processestablishment of integrated proviral latency
GO_1904155Biological processDN2 thymocyte differentiation
GO_0010332Biological processresponse to gamma radiation
GO_0006302Biological processdouble-strand break repair
GO_0033151Biological processV(D)J recombination
GO_0033153Biological processT cell receptor V(D)J recombination
GO_0050769Biological processpositive regulation of neurogenesis
GO_0051301Biological processcell division
GO_0072089Biological processstem cell proliferation
GO_0033152Biological processimmunoglobulin V(D)J recombination
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0033077Biological processT cell differentiation in thymus
GO_0051402Biological processneuron apoptotic process
GO_0071897Biological processDNA biosynthetic process
GO_0022008Biological processneurogenesis
GO_0051276Biological processchromosome organization
GO_0002328Biological processpro-B cell differentiation
GO_0048144Biological processfibroblast proliferation
GO_0051102Biological processDNA ligation involved in DNA recombination
GO_0007417Biological processcentral nervous system development
GO_2001252Biological processpositive regulation of chromosome organization
GO_0045190Biological processisotype switching
GO_0071479Biological processcellular response to ionizing radiation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0035019Biological processsomatic stem cell population maintenance
GO_0006266Biological processDNA ligation
GO_0006297Biological processnucleotide-excision repair, DNA gap filling
GO_0071285Biological processcellular response to lithium ion
GO_0032807Cellular componentDNA ligase IV complex
GO_0005654Cellular componentnucleoplasm
GO_0005958Cellular componentDNA-dependent protein kinase-DNA ligase 4 complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000781Cellular componentchromosome, telomeric region
GO_0000793Cellular componentcondensed chromosome
GO_0070419Cellular componentnonhomologous end joining complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0016874Molecular functionligase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0003910Molecular functionDNA ligase (ATP) activity
GO_0003909Molecular functionDNA ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIG4
Protein nameDNA ligase (EC 6.5.1.1)
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)
Synonyms
DescriptionFUNCTION: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed . Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction . LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps . Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 . Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends . LIG4 regulates nuclear localization of XRCC4 . .

AccessionsENST00000405925.2
ENST00000686095.1
ENST00000689762.1
ENST00000442234.6
ENST00000686926.1
ENST00000693040.1
ENST00000687822.1
ENST00000688455.1
ENST00000688595.1
ENST00000686913.1
ENST00000688396.1
ENST00000690127.1
ENST00000614526.2
ENST00000692222.1
ENST00000687164.1
P49917
ENST00000686204.1
ENST00000611712.4
A0A0C4DGV9
ENST00000685338.1
ENST00000688529.1