LARGE1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	17 studies	39% ± 14%	Explore
oligodendrocyte precursor cell	13 studies	49% ± 20%	Explore
astrocyte	13 studies	40% ± 20%	Explore
GABAergic neuron	11 studies	60% ± 26%	Explore
glutamatergic neuron	11 studies	71% ± 19%	Explore
fibroblast	11 studies	38% ± 15%	Explore
oligodendrocyte	11 studies	34% ± 16%	Explore
pericyte	9 studies	43% ± 19%	Explore
adipocyte	8 studies	32% ± 11%	Explore
microglial cell	8 studies	32% ± 17%	Explore
smooth muscle cell	7 studies	40% ± 13%	Explore
endothelial cell of lymphatic vessel	7 studies	34% ± 12%	Explore
B cell	6 studies	33% ± 10%	Explore
cardiac muscle cell	6 studies	75% ± 17%	Explore
macrophage	6 studies	28% ± 7%	Explore
interneuron	5 studies	72% ± 19%	Explore
neuron	4 studies	49% ± 19%	Explore
mesothelial cell	4 studies	29% ± 3%	Explore
epithelial cell	4 studies	46% ± 27%	Explore
retinal cone cell	4 studies	75% ± 18%	Explore
retinal ganglion cell	4 studies	62% ± 15%	Explore
retinal rod cell	4 studies	60% ± 21%	Explore
type I pneumocyte	4 studies	36% ± 8%	Explore
type II pneumocyte	4 studies	57% ± 11%	Explore
GABAergic amacrine cell	3 studies	26% ± 4%	Explore
Mueller cell	3 studies	25% ± 8%	Explore
OFF-bipolar cell	3 studies	39% ± 8%	Explore
ON-bipolar cell	3 studies	36% ± 9%	Explore
glycinergic amacrine cell	3 studies	24% ± 5%	Explore
myeloid cell	3 studies	29% ± 8%	Explore
endothelial cell of vascular tree	3 studies	32% ± 8%	Explore
amacrine cell	3 studies	27% ± 8%	Explore
neural progenitor cell	3 studies	29% ± 3%	Explore
ciliated cell	3 studies	26% ± 6%	Explore
club cell	3 studies	41% ± 11%	Explore
basal cell	3 studies	39% ± 18%	Explore
granule cell	3 studies	51% ± 34%	Explore
plasma cell	3 studies	34% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	49% ± 24%	Explore
heart	5 studies	43% ± 14%	Explore
eye	5 studies	48% ± 10%	Explore
lung	4 studies	30% ± 7%	Explore
kidney	3 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	2650.55	359 / 359	96%	6.40	275 / 286
prostate	100%	2979.94	245 / 245	96%	6.29	481 / 502
breast	100%	1958.83	459 / 459	96%	10.92	1070 / 1118
brain	94%	2680.03	2479 / 2642	99%	11.79	700 / 705
intestine	100%	3919.75	966 / 966	92%	5.52	487 / 527
thymus	99%	1158.80	644 / 653	90%	5.07	543 / 605
skin	98%	1317.27	1765 / 1809	90%	9.57	425 / 472
pancreas	88%	739.29	290 / 328	95%	5.74	169 / 178
bladder	100%	4295.33	21 / 21	82%	5.38	414 / 504
ovary	100%	3047.28	180 / 180	82%	4.53	351 / 430
lung	98%	1329.38	569 / 578	81%	5.50	935 / 1155
liver	93%	841.00	211 / 226	84%	4.59	341 / 406
esophagus	88%	1830.87	1272 / 1445	85%	5.54	156 / 183
kidney	99%	1310.43	88 / 89	74%	3.01	667 / 901
uterus	99%	3975.14	169 / 170	66%	5.35	305 / 459
adrenal gland	100%	1993.41	258 / 258	66%	4.02	151 / 230
adipose	100%	2148.93	1204 / 1204	0%	0	0 / 0
muscle	100%	4916.39	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.89	1 / 1
blood vessel	100%	2706.21	1334 / 1335	0%	0	0 / 0
spleen	99%	1195.10	238 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	99%	9.24	79 / 80
heart	98%	5904.12	842 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	73%	5.46	33 / 45
lymph node	0%	0	0 / 0	45%	2.47	13 / 29
peripheral blood	15%	302.61	142 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006941	Biological process	striated muscle contraction
GO_0007605	Biological process	sensory perception of sound
GO_0060291	Biological process	long-term synaptic potentiation
GO_0006044	Biological process	N-acetylglucosamine metabolic process
GO_0072659	Biological process	protein localization to plasma membrane
GO_0046716	Biological process	muscle cell cellular homeostasis
GO_0042552	Biological process	myelination
GO_0021675	Biological process	nerve development
GO_0150103	Biological process	reactive gliosis
GO_0030225	Biological process	macrophage differentiation
GO_0008340	Biological process	determination of adult lifespan
GO_0055013	Biological process	cardiac muscle cell development
GO_0048741	Biological process	skeletal muscle fiber development
GO_0095500	Biological process	acetylcholine receptor signaling pathway
GO_0021542	Biological process	dentate gyrus development
GO_0061448	Biological process	connective tissue development
GO_0035264	Biological process	multicellular organism growth
GO_0006886	Biological process	intracellular protein transport
GO_0006486	Biological process	protein glycosylation
GO_0043403	Biological process	skeletal muscle tissue regeneration
GO_0001764	Biological process	neuron migration
GO_0007010	Biological process	cytoskeleton organization
GO_0006612	Biological process	protein targeting to membrane
GO_0051674	Biological process	localization of cell
GO_0035129	Biological process	post-embryonic hindlimb morphogenesis
GO_0007274	Biological process	neuromuscular synaptic transmission
GO_0009101	Biological process	glycoprotein biosynthetic process
GO_0048708	Biological process	astrocyte differentiation
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0043687	Biological process	post-translational protein modification
GO_0050884	Biological process	neuromuscular process controlling posture
GO_0065003	Biological process	protein-containing complex assembly
GO_0061298	Biological process	retina vasculature development in camera-type eye
GO_0051124	Biological process	synaptic assembly at neuromuscular junction
GO_0071711	Biological process	basement membrane organization
GO_0006833	Biological process	water transport
GO_0055002	Biological process	striated muscle cell development
GO_0006493	Biological process	protein O-linked glycosylation
GO_0007009	Biological process	plasma membrane organization
GO_0021740	Biological process	principal sensory nucleus of trigeminal nerve development
GO_0001568	Biological process	blood vessel development
GO_0009416	Biological process	response to light stimulus
GO_0098528	Biological process	skeletal muscle fiber differentiation
GO_0001662	Biological process	behavioral fear response
GO_0007613	Biological process	memory
GO_0010467	Biological process	gene expression
GO_0060538	Biological process	skeletal muscle organ development
GO_0009612	Biological process	response to mechanical stimulus
GO_0060348	Biological process	bone development
GO_0006688	Biological process	glycosphingolipid biosynthetic process
GO_0090659	Biological process	walking behavior
GO_0035269	Biological process	protein O-linked mannosylation
GO_0010842	Biological process	retina layer formation
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0032991	Cellular component	protein-containing complex
GO_0005794	Cellular component	Golgi apparatus
GO_0000139	Cellular component	Golgi membrane
GO_0016758	Molecular function	hexosyltransferase activity
GO_0015020	Molecular function	glucuronosyltransferase activity
GO_0030145	Molecular function	manganese ion binding
GO_0008375	Molecular function	acetylglucosaminyltransferase activity
GO_0016757	Molecular function	glycosyltransferase activity
GO_0042285	Molecular function	xylosyltransferase activity
GO_0035252	Molecular function	UDP-xylosyltransferase activity

IV. Literature review

[source]

Gene name	LARGE1
Protein name	Glycosyltransferase-like protein isoform A (Like-glycosyltransferase, isoform CRA_a) LARGE xylosyl- and glucuronyltransferase 1 Alternative protein LARGE Glycosyltransferase-like protein isoform B Like-glycosyltransferase Glycosyltransferase-like protein isoform C (LARGE xylosyl- and glucuronyltransferase 1) Glycosyltransferase-like protein isoform D Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)]
Synonyms	CTA-282F2.2-010 CTA-282F2.2-013 CTA-282F2.2-012 KIAA0609 LARGE hCG_1776784 CTA-282F2.2-014
Description	FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity . Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide . Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer . Plays a key role in skeletal muscle function and regeneration (By similarity). .
Accessions	ENST00000413114 ENST00000676132.1 [O95461-1] ENST00000397394.8 [O95461-1] A0A6Q8PFT0 ENST00000675416.1 [O95461-1] ENST00000608642.6 L8ECB5 ENST00000676370.1 [O95461-1] ENST00000434071.6 A0A6Q8PFY8 ENST00000674999.1 V9GY39 ENST00000609799.6 ENST00000430220.7 B0QY08 ENST00000421768.2 ENST00000674668.1 ENST00000674543.1 B0QYZ8 X5DRG1 ENST00000676126.1 V9GY56 ENST00000476315.2 ENST00000402320.6 [O95461-2] A0A6Q8PFW0 ENST00000413114.6 [O95461-1] X5DR28 ENST00000676031.1 A0A6Q8PF85 X5D9N1 ENST00000674780.1 ENST00000432776.6 B7ZB85 B0QYZ9 B7ZB84 B0QY11 A0A6Q8PHK1 A0A6Q8PHF1 ENST00000674789.1 V9GYK8 A0A6Q8PF10 ENST00000675277.1 ENST00000423375.2 O95461 ENST00000675382.1 B0QY09 ENST00000676070.1 [O95461-1] X5DRJ7 ENST00000354992.7 [O95461-1] A0A6Q8PG57 ENST00000610186.6

LARGE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review