Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 26% ± 11% | |
oligodendrocyte | 11 studies | 29% ± 10% | |
glutamatergic neuron | 10 studies | 41% ± 27% | |
microglial cell | 10 studies | 27% ± 10% | |
astrocyte | 10 studies | 31% ± 14% | |
oligodendrocyte precursor cell | 9 studies | 28% ± 12% | |
ciliated cell | 8 studies | 23% ± 7% | |
adipocyte | 7 studies | 24% ± 5% | |
GABAergic neuron | 7 studies | 41% ± 23% | |
neuron | 6 studies | 33% ± 16% | |
fibroblast | 6 studies | 23% ± 7% | |
macrophage | 6 studies | 30% ± 10% | |
dendritic cell | 5 studies | 20% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 9% | |
smooth muscle cell | 5 studies | 20% ± 2% | |
type II pneumocyte | 5 studies | 21% ± 5% | |
interneuron | 5 studies | 43% ± 23% | |
myeloid cell | 4 studies | 19% ± 2% | |
epithelial cell | 4 studies | 39% ± 12% | |
cardiac muscle cell | 4 studies | 17% ± 1% | |
lymphocyte | 4 studies | 23% ± 9% | |
retinal rod cell | 4 studies | 27% ± 5% | |
pericyte | 4 studies | 27% ± 9% | |
type I pneumocyte | 4 studies | 22% ± 5% | |
GABAergic interneuron | 3 studies | 22% ± 5% | |
B cell | 3 studies | 19% ± 3% | |
retinal cone cell | 3 studies | 22% ± 6% | |
hepatocyte | 3 studies | 42% ± 26% | |
ependymal cell | 3 studies | 32% ± 11% | |
club cell | 3 studies | 20% ± 6% | |
T cell | 3 studies | 17% ± 2% | |
alveolar macrophage | 3 studies | 25% ± 8% | |
monocyte | 3 studies | 24% ± 2% | |
natural killer cell | 3 studies | 17% ± 1% | |
basal cell | 3 studies | 30% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2859.85 | 1445 / 1445 | 100% | 22.39 | 183 / 183 |
lung | 100% | 3084.63 | 578 / 578 | 100% | 19.39 | 1155 / 1155 |
ovary | 100% | 2323.18 | 180 / 180 | 100% | 13.20 | 430 / 430 |
stomach | 100% | 2118.45 | 359 / 359 | 100% | 15.20 | 286 / 286 |
breast | 100% | 2913.98 | 459 / 459 | 100% | 21.58 | 1117 / 1118 |
intestine | 100% | 3007.52 | 966 / 966 | 100% | 14.22 | 526 / 527 |
bladder | 100% | 3138.95 | 21 / 21 | 100% | 15.04 | 503 / 504 |
prostate | 100% | 2814.18 | 245 / 245 | 100% | 16.18 | 501 / 502 |
uterus | 100% | 2980.59 | 170 / 170 | 100% | 19.01 | 458 / 459 |
liver | 100% | 1897.24 | 226 / 226 | 100% | 10.39 | 405 / 406 |
brain | 100% | 2391.42 | 2629 / 2642 | 100% | 21.90 | 705 / 705 |
thymus | 100% | 2730.71 | 653 / 653 | 100% | 15.14 | 602 / 605 |
pancreas | 100% | 1494.15 | 328 / 328 | 99% | 14.11 | 177 / 178 |
skin | 100% | 3079.16 | 1808 / 1809 | 99% | 16.99 | 469 / 472 |
kidney | 100% | 1768.18 | 89 / 89 | 99% | 13.03 | 893 / 901 |
adrenal gland | 100% | 3096.86 | 258 / 258 | 99% | 10.61 | 227 / 230 |
adipose | 100% | 3052.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3302.50 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.87 | 29 / 29 |
muscle | 100% | 8803.51 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2824.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 23.03 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.90 | 1 / 1 |
peripheral blood | 98% | 2375.58 | 915 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 2391.13 | 845 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 7.48 | 71 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0014841 | Biological process | skeletal muscle satellite cell proliferation |
GO_0000018 | Biological process | regulation of DNA recombination |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0006606 | Biological process | protein import into nucleus |
GO_0099527 | Biological process | postsynapse to nucleus signaling pathway |
GO_0060828 | Biological process | regulation of canonical Wnt signaling pathway |
GO_0006607 | Biological process | NLS-bearing protein import into nucleus |
GO_0014901 | Biological process | satellite cell activation involved in skeletal muscle regeneration |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005643 | Cellular component | nuclear pore |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0042564 | Cellular component | NLS-dependent protein nuclear import complex |
GO_0005829 | Cellular component | cytosol |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0008139 | Molecular function | nuclear localization sequence binding |
GO_0061608 | Molecular function | nuclear import signal receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | KPNA1 |
Protein name | Importin subunit alpha Karyopherin subunit alpha 1 Alternative protein KPNA1 Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] Importin subunit alpha-5 (Karyopherin subunit alpha-1) |
Synonyms | RCH2 |
Description | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 . Binds specifically and directly to substrates containing either a simple or bipartite NLS motif . Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism . At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin . The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . .; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. . FUNCTION: Functions in nuclear protein import. . |
Accessions | ENST00000482287.5 C9J352 ENST00000465882.5 C9J4U1 ENST00000485027.5 ENST00000344337.11 C9JYI4 ENST00000476916.5 L8EC94 P52294 C9JWD9 ENST00000493510.1 Q5BKZ2 F2Z3G4 ENST00000494339.5 |