KPNA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014841Biological processskeletal muscle satellite cell proliferation
GO_0000018Biological processregulation of DNA recombination
GO_0042981Biological processregulation of apoptotic process
GO_0006606Biological processprotein import into nucleus
GO_0099527Biological processpostsynapse to nucleus signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0014901Biological processsatellite cell activation involved in skeletal muscle regeneration
GO_0098978Cellular componentglutamatergic synapse
GO_0005643Cellular componentnuclear pore
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0061608Molecular functionnuclear import signal receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKPNA1
Protein nameImportin subunit alpha
Karyopherin subunit alpha 1
Alternative protein KPNA1
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Importin subunit alpha-5 (Karyopherin subunit alpha-1)
SynonymsRCH2
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 . Binds specifically and directly to substrates containing either a simple or bipartite NLS motif . Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism . At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin . The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . .; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. .

FUNCTION: Functions in nuclear protein import. .

AccessionsENST00000482287.5
C9J352
ENST00000465882.5
C9J4U1
ENST00000485027.5
ENST00000344337.11
C9JYI4
ENST00000476916.5
L8EC94
P52294
C9JWD9
ENST00000493510.1
Q5BKZ2
F2Z3G4
ENST00000494339.5