Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 26% ± 9% | |
oligodendrocyte | 10 studies | 31% ± 11% | |
fibroblast | 9 studies | 21% ± 4% | |
astrocyte | 9 studies | 34% ± 13% | |
glutamatergic neuron | 8 studies | 42% ± 24% | |
ciliated cell | 8 studies | 26% ± 12% | |
microglial cell | 8 studies | 26% ± 10% | |
oligodendrocyte precursor cell | 8 studies | 34% ± 15% | |
epithelial cell | 7 studies | 36% ± 14% | |
GABAergic neuron | 7 studies | 44% ± 16% | |
pericyte | 7 studies | 20% ± 3% | |
club cell | 6 studies | 22% ± 8% | |
retina horizontal cell | 6 studies | 22% ± 5% | |
adipocyte | 6 studies | 25% ± 5% | |
type II pneumocyte | 6 studies | 21% ± 6% | |
neuron | 5 studies | 47% ± 14% | |
retinal cone cell | 5 studies | 23% ± 6% | |
retinal rod cell | 5 studies | 23% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 24% ± 3% | |
goblet cell | 5 studies | 30% ± 18% | |
smooth muscle cell | 5 studies | 19% ± 3% | |
macrophage | 5 studies | 28% ± 5% | |
type I pneumocyte | 5 studies | 21% ± 5% | |
interneuron | 5 studies | 45% ± 18% | |
myeloid cell | 4 studies | 20% ± 1% | |
amacrine cell | 4 studies | 24% ± 4% | |
retinal bipolar neuron | 4 studies | 22% ± 5% | |
cardiac muscle cell | 4 studies | 22% ± 1% | |
lymphocyte | 4 studies | 22% ± 3% | |
basal cell | 4 studies | 28% ± 11% | |
monocyte | 4 studies | 24% ± 2% | |
T cell | 4 studies | 17% ± 1% | |
natural killer cell | 3 studies | 18% ± 2% | |
GABAergic amacrine cell | 3 studies | 24% ± 6% | |
glycinergic amacrine cell | 3 studies | 28% ± 7% | |
rod bipolar cell | 3 studies | 24% ± 4% | |
respiratory goblet cell | 3 studies | 18% ± 2% | |
hepatocyte | 3 studies | 31% ± 13% | |
dendritic cell | 3 studies | 24% ± 6% | |
abnormal cell | 3 studies | 25% ± 12% | |
ependymal cell | 3 studies | 34% ± 12% | |
connective tissue cell | 3 studies | 17% ± 2% | |
enteroendocrine cell | 3 studies | 25% ± 6% | |
myofibroblast cell | 3 studies | 23% ± 2% | |
granule cell | 3 studies | 26% ± 5% | |
mast cell | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 3501.12 | 459 / 459 | 100% | 34.55 | 1118 / 1118 |
esophagus | 100% | 3228.30 | 1445 / 1445 | 100% | 21.61 | 183 / 183 |
intestine | 100% | 3733.89 | 966 / 966 | 100% | 17.87 | 527 / 527 |
ovary | 100% | 4057.34 | 180 / 180 | 100% | 17.65 | 430 / 430 |
prostate | 100% | 4455.11 | 245 / 245 | 100% | 31.75 | 502 / 502 |
stomach | 100% | 2898.23 | 359 / 359 | 100% | 17.78 | 286 / 286 |
brain | 100% | 2897.90 | 2641 / 2642 | 100% | 26.71 | 705 / 705 |
lung | 100% | 2673.96 | 577 / 578 | 100% | 21.58 | 1155 / 1155 |
bladder | 100% | 3513.10 | 21 / 21 | 100% | 18.99 | 503 / 504 |
thymus | 100% | 5023.64 | 653 / 653 | 100% | 29.11 | 603 / 605 |
uterus | 100% | 4706.95 | 170 / 170 | 100% | 19.86 | 457 / 459 |
pancreas | 100% | 2216.02 | 328 / 328 | 99% | 20.01 | 177 / 178 |
kidney | 100% | 2722.87 | 89 / 89 | 99% | 18.07 | 889 / 901 |
adrenal gland | 100% | 3245.11 | 258 / 258 | 97% | 13.40 | 224 / 230 |
liver | 100% | 2096.58 | 226 / 226 | 97% | 12.51 | 392 / 406 |
skin | 100% | 3085.42 | 1809 / 1809 | 96% | 19.56 | 451 / 472 |
adipose | 100% | 3070.12 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3162.20 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.82 | 29 / 29 |
spleen | 100% | 3421.68 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.97 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.87 | 1 / 1 |
muscle | 100% | 2144.42 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 100% | 1871.26 | 857 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 1749.35 | 880 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 11.26 | 72 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2001034 | Biological process | positive regulation of double-strand break repair via nonhomologous end joining |
GO_0006281 | Biological process | DNA repair |
GO_0032259 | Biological process | methylation |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045830 | Biological process | positive regulation of isotype switching |
GO_0007517 | Biological process | muscle organ development |
GO_0000779 | Cellular component | condensed chromosome, centromeric region |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_1904047 | Molecular function | S-adenosyl-L-methionine binding |
GO_0140944 | Molecular function | histone H4K20 monomethyltransferase activity |
GO_0042054 | Molecular function | histone methyltransferase activity |
GO_0140939 | Molecular function | histone H4 methyltransferase activity |
GO_0140941 | Molecular function | histone H4K20me methyltransferase activity |
GO_0042799 | Molecular function | histone H4K20 methyltransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0003682 | Molecular function | chromatin binding |
Gene name | KMT5B |
Protein name | [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B (EC 2.1.1.361) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) Lysine methyltransferase 5B |
Synonyms | CGI-85 SUV420H1 |
Description | FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity . In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes . H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 . Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 . May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). . |
Accessions | ENST00000700524.1 C9J6S5 C9JP58 ENST00000401547.6 [Q4FZB7-2] H7BXP2 A0A8V8TR96 ENST00000405515.5 [Q4FZB7-2] ENST00000453170.6 ENST00000304363.9 [Q4FZB7-1] C9JFG1 ENST00000615954.4 [Q4FZB7-1] ENST00000402185.6 ENST00000323599.10 ENST00000402789.5 A0A8V8TQY7 B7WNX0 ENST00000458496.2 ENST00000700521.1 ENST00000700523.1 B5MCB3 ENST00000434573.1 F8WFA4 A0A8V8TQA0 Q4FZB7 ENST00000441488.6 [Q4FZB7-4] ENST00000700520.1 ENST00000427752.6 ENST00000700522.1 A0A8V8TPR6 A0A8V8TQB9 |