KMT5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0006281Biological processDNA repair
GO_0032259Biological processmethylation
GO_0006338Biological processchromatin remodeling
GO_0045830Biological processpositive regulation of isotype switching
GO_0007517Biological processmuscle organ development
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0140944Molecular functionhistone H4K20 monomethyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0140939Molecular functionhistone H4 methyltransferase activity
GO_0140941Molecular functionhistone H4K20me methyltransferase activity
GO_0042799Molecular functionhistone H4K20 methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameKMT5B
Protein name[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B (EC 2.1.1.361) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B)
Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
Lysine methyltransferase 5B
SynonymsCGI-85
SUV420H1
DescriptionFUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity . In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes . H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 . Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 . May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). .

AccessionsENST00000700524.1
C9J6S5
C9JP58
ENST00000401547.6 [Q4FZB7-2]
H7BXP2
A0A8V8TR96
ENST00000405515.5 [Q4FZB7-2]
ENST00000453170.6
ENST00000304363.9 [Q4FZB7-1]
C9JFG1
ENST00000615954.4 [Q4FZB7-1]
ENST00000402185.6
ENST00000323599.10
ENST00000402789.5
A0A8V8TQY7
B7WNX0
ENST00000458496.2
ENST00000700521.1
ENST00000700523.1
B5MCB3
ENST00000434573.1
F8WFA4
A0A8V8TQA0
Q4FZB7
ENST00000441488.6 [Q4FZB7-4]
ENST00000700520.1
ENST00000427752.6
ENST00000700522.1
A0A8V8TPR6
A0A8V8TQB9