Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 8 studies | 26% ± 5% | |
| endothelial cell | 7 studies | 24% ± 11% | |
| myofibroblast cell | 6 studies | 21% ± 3% | |
| connective tissue cell | 6 studies | 24% ± 8% | |
| pericyte | 6 studies | 35% ± 12% | |
| smooth muscle cell | 6 studies | 23% ± 8% | |
| natural killer cell | 6 studies | 21% ± 3% | |
| glutamatergic neuron | 5 studies | 34% ± 19% | |
| neuron | 4 studies | 32% ± 16% | |
| epithelial cell | 4 studies | 37% ± 17% | |
| hematopoietic precursor cell | 3 studies | 27% ± 7% | |
| conventional dendritic cell | 3 studies | 25% ± 7% | |
| naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 18% ± 3% | |
| non-classical monocyte | 3 studies | 21% ± 3% | |
| retinal ganglion cell | 3 studies | 54% ± 26% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 21% ± 3% | |
| macrophage | 3 studies | 20% ± 5% | |
| amacrine cell | 3 studies | 38% ± 10% | |
| oligodendrocyte precursor cell | 3 studies | 22% ± 3% | |
| intestinal crypt stem cell | 3 studies | 16% ± 1% | |
| CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
| plasmacytoid dendritic cell | 3 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 4815.43 | 180 / 180 | 100% | 219.01 | 430 / 430 |
| thymus | 100% | 4850.19 | 653 / 653 | 100% | 180.77 | 605 / 605 |
| brain | 100% | 11159.01 | 2641 / 2642 | 100% | 317.84 | 705 / 705 |
| esophagus | 100% | 5207.03 | 1444 / 1445 | 100% | 134.23 | 183 / 183 |
| prostate | 100% | 5358.59 | 245 / 245 | 100% | 192.07 | 501 / 502 |
| uterus | 100% | 4391.24 | 170 / 170 | 100% | 230.18 | 458 / 459 |
| skin | 100% | 4076.97 | 1808 / 1809 | 100% | 209.70 | 471 / 472 |
| breast | 100% | 4975.31 | 459 / 459 | 100% | 191.74 | 1115 / 1118 |
| adrenal gland | 100% | 5548.51 | 258 / 258 | 100% | 200.57 | 229 / 230 |
| liver | 100% | 3353.84 | 225 / 226 | 100% | 166.54 | 406 / 406 |
| intestine | 100% | 5519.19 | 966 / 966 | 99% | 143.26 | 524 / 527 |
| lung | 99% | 4030.66 | 574 / 578 | 100% | 155.23 | 1152 / 1155 |
| bladder | 100% | 4448.95 | 21 / 21 | 99% | 184.77 | 499 / 504 |
| stomach | 100% | 4610.77 | 359 / 359 | 99% | 134.78 | 283 / 286 |
| kidney | 100% | 4175.17 | 89 / 89 | 99% | 115.86 | 890 / 901 |
| pancreas | 96% | 2518.63 | 315 / 328 | 99% | 135.06 | 177 / 178 |
| eye | 0% | 0 | 0 / 0 | 100% | 304.14 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 194.05 | 29 / 29 |
| spleen | 100% | 4840.27 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 172.67 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 128.83 | 1 / 1 |
| adipose | 100% | 4543.47 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 7830.24 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5086.02 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 5467.53 | 846 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 86% | 2770.23 | 799 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007131 | Biological process | reciprocal meiotic recombination |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0140627 | Biological process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0031462 | Cellular component | Cul2-RING ubiquitin ligase complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | KLHDC3 |
| Protein name | Kelch domain-containing protein 3 (Testis intracellular mediator protein) KLHDC3 protein Kelch domain containing 3 |
| Synonyms | PEAS |
| Description | FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons . The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine . May be involved in meiotic recombination process . . |
| Accessions | Q8IVW5 ENST00000244670.12 F8W6A4 ENST00000326974.9 Q9BQ90 |