KLHDC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007131Biological processreciprocal meiotic recombination
GO_0016567Biological processprotein ubiquitination
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameKLHDC3
Protein nameKelch domain-containing protein 3 (Testis intracellular mediator protein)
KLHDC3 protein
Kelch domain containing 3
SynonymsPEAS
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons . The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine . May be involved in meiotic recombination process . .

AccessionsQ8IVW5
ENST00000244670.12
F8W6A4
ENST00000326974.9
Q9BQ90