JOSD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	9 studies	21% ± 4%	Explore
natural killer cell	8 studies	22% ± 5%	Explore
epithelial cell	8 studies	31% ± 18%	Explore
classical monocyte	7 studies	20% ± 4%	Explore
B cell	6 studies	21% ± 3%	Explore
T cell	6 studies	21% ± 7%	Explore
endothelial cell	6 studies	21% ± 4%	Explore
mast cell	5 studies	20% ± 3%	Explore
dendritic cell	4 studies	26% ± 10%	Explore
leukocyte	4 studies	24% ± 3%	Explore
naive B cell	4 studies	20% ± 5%	Explore
non-classical monocyte	4 studies	25% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	27% ± 6%	Explore
conventional dendritic cell	4 studies	28% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	27% ± 8%	Explore
gamma-delta T cell	4 studies	29% ± 11%	Explore
goblet cell	4 studies	19% ± 2%	Explore
monocyte	3 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	27% ± 4%	Explore
CD4-positive, alpha-beta T cell	3 studies	24% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	35% ± 6%	Explore
mature NK T cell	3 studies	26% ± 5%	Explore
myeloid cell	3 studies	28% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore
regulatory T cell	3 studies	22% ± 8%	Explore
type I pneumocyte	3 studies	19% ± 3%	Explore
GABAergic neuron	3 studies	33% ± 10%	Explore
glutamatergic neuron	3 studies	44% ± 13%	Explore
basal cell	3 studies	23% ± 3%	Explore
oligodendrocyte	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	19% ± 5%	Explore
brain	5 studies	26% ± 10%	Explore
peripheral blood	4 studies	26% ± 2%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4015.22	1445 / 1445	100%	72.31	183 / 183
lung	100%	5515.69	578 / 578	100%	78.01	1155 / 1155
stomach	100%	3357.26	359 / 359	100%	55.12	286 / 286
breast	100%	4555.34	459 / 459	100%	61.70	1117 / 1118
brain	100%	3780.60	2637 / 2642	100%	50.43	705 / 705
intestine	100%	5283.82	966 / 966	100%	61.13	526 / 527
skin	100%	4736.02	1809 / 1809	100%	74.21	471 / 472
pancreas	100%	2233.47	327 / 328	100%	69.35	178 / 178
bladder	100%	4272.52	21 / 21	100%	59.45	502 / 504
prostate	100%	4258.62	245 / 245	100%	44.50	500 / 502
uterus	100%	4498.84	170 / 170	100%	71.86	457 / 459
ovary	100%	8004.80	180 / 180	100%	36.97	428 / 430
thymus	100%	4188.35	653 / 653	99%	44.73	598 / 605
kidney	100%	3113.27	89 / 89	99%	46.76	888 / 901
liver	100%	2158.06	225 / 226	96%	33.72	391 / 406
adrenal gland	100%	3558.38	258 / 258	92%	29.84	211 / 230
adipose	100%	5269.23	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5092.69	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	41.79	80 / 80
lymph node	0%	0	0 / 0	100%	47.03	29 / 29
spleen	100%	3960.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	76.01	45 / 45
ureter	0%	0	0 / 0	100%	36.88	1 / 1
muscle	99%	2389.79	797 / 803	0%	0	0 / 0
heart	99%	2603.37	854 / 861	0%	0	0 / 0
peripheral blood	98%	4748.78	913 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006508	Biological process	proteolysis
GO_0016579	Biological process	protein deubiquitination
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

IV. Literature review

[source]

Gene name	JOSD1
Protein name	Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)
Synonyms	KIAA0063 JSPH1
Description	FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. . FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. . FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. . FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. . FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. . FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. .
Accessions	B0QY55 H0YGT9 ENST00000456626.1 ENST00000427389.5 ENST00000545590.1 ENST00000417712.1 ENST00000683374.1 ENST00000412832.1 B0QY58 ENST00000216039.9 B0QY56 B0QY57 Q15040

JOSD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review