JAM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	33% ± 18%	Explore
oligodendrocyte	16 studies	54% ± 17%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 13%	Explore
glutamatergic neuron	8 studies	43% ± 23%	Explore
capillary endothelial cell	8 studies	24% ± 7%	Explore
fibroblast	7 studies	23% ± 7%	Explore
GABAergic neuron	7 studies	37% ± 16%	Explore
interneuron	6 studies	30% ± 13%	Explore
retinal rod cell	6 studies	34% ± 16%	Explore
neuron	5 studies	32% ± 17%	Explore
astrocyte	5 studies	26% ± 7%	Explore
pericyte	4 studies	21% ± 6%	Explore
smooth muscle cell	4 studies	20% ± 3%	Explore
glomerular endothelial cell	3 studies	21% ± 1%	Explore
glial cell	3 studies	31% ± 3%	Explore
granule cell	3 studies	30% ± 12%	Explore
platelet	3 studies	25% ± 4%	Explore
connective tissue cell	3 studies	26% ± 8%	Explore
myofibroblast cell	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	37% ± 19%	Explore
eye	4 studies	30% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4132.00	2619 / 2642	99%	30.63	695 / 705
prostate	100%	4927.74	244 / 245	85%	9.89	425 / 502
breast	99%	3231.41	455 / 459	78%	7.42	873 / 1118
adrenal gland	100%	2786.63	258 / 258	77%	12.90	176 / 230
lung	100%	4606.26	576 / 578	67%	5.86	769 / 1155
thymus	99%	2724.84	645 / 653	67%	6.83	407 / 605
skin	93%	2814.41	1680 / 1809	68%	13.34	323 / 472
kidney	83%	1444.80	74 / 89	67%	10.49	608 / 901
intestine	94%	5809.39	912 / 966	47%	3.59	248 / 527
ovary	100%	7207.39	180 / 180	40%	2.70	171 / 430
esophagus	83%	5038.28	1203 / 1445	56%	4.40	102 / 183
bladder	100%	6568.76	21 / 21	35%	2.96	175 / 504
stomach	75%	2974.94	270 / 359	58%	6.64	166 / 286
uterus	99%	6567.75	169 / 170	27%	4.95	124 / 459
blood vessel	100%	10634.09	1335 / 1335	0%	0	0 / 0
adipose	100%	3351.70	1198 / 1204	0%	0	0 / 0
spleen	98%	2089.05	237 / 241	0%	0	0 / 0
heart	98%	2872.44	842 / 861	0%	0	0 / 0
pancreas	6%	76.06	19 / 328	85%	9.77	152 / 178
eye	0%	0	0 / 0	69%	6.50	55 / 80
tonsil	0%	0	0 / 0	29%	1.34	13 / 45
lymph node	0%	0	0 / 0	17%	0.76	5 / 29
muscle	16%	239.44	128 / 803	0%	0	0 / 0
liver	2%	27.23	5 / 226	13%	0.76	54 / 406
peripheral blood	2%	25.14	15 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001780	Biological process	neutrophil homeostasis
GO_0030010	Biological process	establishment of cell polarity
GO_0001525	Biological process	angiogenesis
GO_0097530	Biological process	granulocyte migration
GO_0034333	Biological process	adherens junction assembly
GO_0042552	Biological process	myelination
GO_0090138	Biological process	regulation of actin cytoskeleton organization by cell-cell adhesion
GO_1905710	Biological process	positive regulation of membrane permeability
GO_0007160	Biological process	cell-matrix adhesion
GO_0002523	Biological process	leukocyte migration involved in inflammatory response
GO_1902414	Biological process	protein localization to cell junction
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0045176	Biological process	apical protein localization
GO_0033629	Biological process	negative regulation of cell adhesion mediated by integrin
GO_0034394	Biological process	protein localization to cell surface
GO_0090022	Biological process	regulation of neutrophil chemotaxis
GO_2000439	Biological process	positive regulation of monocyte extravasation
GO_0002250	Biological process	adaptive immune response
GO_0097241	Biological process	hematopoietic stem cell migration to bone marrow
GO_0033624	Biological process	negative regulation of integrin activation
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0019226	Biological process	transmission of nerve impulse
GO_0002318	Biological process	myeloid progenitor cell differentiation
GO_0098609	Biological process	cell-cell adhesion
GO_0016477	Biological process	cell migration
GO_0007286	Biological process	spermatid development
GO_0005902	Cellular component	microvillus
GO_0005615	Cellular component	extracellular space
GO_0070160	Cellular component	tight junction
GO_0031941	Cellular component	filamentous actin
GO_0005886	Cellular component	plasma membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0044291	Cellular component	cell-cell contact zone
GO_0005911	Cellular component	cell-cell junction
GO_0043220	Cellular component	Schmidt-Lanterman incisure
GO_0033010	Cellular component	paranodal junction
GO_0098636	Cellular component	protein complex involved in cell adhesion
GO_0005923	Cellular component	bicellular tight junction
GO_0030057	Cellular component	desmosome
GO_0042803	Molecular function	protein homodimerization activity
GO_0098632	Molecular function	cell-cell adhesion mediator activity
GO_0005178	Molecular function	integrin binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	JAM3
Protein name	Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] Junctional adhesion molecule 3
Synonyms	UNQ859/PRO1868
Description	FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes . Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 . Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) . Plays a role in angiogenesis . Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). .; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. .
Accessions	ENST00000441717.3 [Q9BX67-2] Q9BX67 ENST00000534549.5 ENST00000532252.5 H0YCW9 ENST00000299106.9 [Q9BX67-1] H0YD98

JAM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review