IRAK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0043330Biological processresponse to exogenous dsRNA
GO_0009615Biological processresponse to virus
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0070555Biological processresponse to interleukin-1
GO_0010933Biological processpositive regulation of macrophage tolerance induction
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032494Biological processresponse to peptidoglycan
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045824Biological processnegative regulation of innate immune response
GO_0035556Biological processintracellular signal transduction
GO_0043242Biological processnegative regulation of protein-containing complex disassembly
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_0001819Biological processpositive regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0008063Biological processToll signaling pathway
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0001960Biological processnegative regulation of cytokine-mediated signaling pathway
GO_0032496Biological processresponse to lipopolysaccharide
GO_0043244Biological processregulation of protein-containing complex disassembly
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRAK3
Protein nameInterleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
Interleukin 1 receptor associated kinase 3
Synonyms
DescriptionFUNCTION: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors . Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells . .

AccessionsENST00000261233.9 [Q9Y616-1]
ENST00000545837.1
F5GYN6
Q9Y616
ENST00000457197.2 [Q9Y616-2]