INTS11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	8 studies	26% ± 7%	Explore
endothelial cell	8 studies	23% ± 6%	Explore
CD8-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
natural killer cell	8 studies	22% ± 4%	Explore
regulatory T cell	8 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 2%	Explore
CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
epithelial cell	6 studies	33% ± 13%	Explore
plasmacytoid dendritic cell	6 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	19% ± 3%	Explore
fibroblast	5 studies	22% ± 7%	Explore
myofibroblast cell	5 studies	17% ± 1%	Explore
B cell	5 studies	19% ± 5%	Explore
gamma-delta T cell	5 studies	23% ± 13%	Explore
hematopoietic precursor cell	4 studies	22% ± 8%	Explore
classical monocyte	4 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
glutamatergic neuron	4 studies	36% ± 15%	Explore
mucosal invariant T cell	4 studies	18% ± 2%	Explore
smooth muscle cell	4 studies	19% ± 3%	Explore
basal cell	4 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	17% ± 2%	Explore
plasmablast	3 studies	45% ± 5%	Explore
conventional dendritic cell	3 studies	33% ± 13%	Explore
exhausted T cell	3 studies	20% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
non-classical monocyte	3 studies	29% ± 5%	Explore
neuron	3 studies	26% ± 8%	Explore
pericyte	3 studies	20% ± 2%	Explore
type I pneumocyte	3 studies	21% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
GABAergic neuron	3 studies	32% ± 11%	Explore
astrocyte	3 studies	22% ± 3%	Explore
dendritic cell	3 studies	34% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
oligodendrocyte	3 studies	19% ± 2%	Explore
memory B cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	20% ± 6%	Explore
lung	5 studies	21% ± 6%	Explore
brain	4 studies	27% ± 10%	Explore
liver	3 studies	24% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8151.09	1445 / 1445	100%	32.21	183 / 183
ovary	100%	11509.99	180 / 180	100%	34.57	430 / 430
pancreas	100%	5010.59	328 / 328	100%	33.69	178 / 178
thymus	100%	8924.96	653 / 653	100%	41.38	605 / 605
uterus	100%	14371.97	170 / 170	100%	44.52	459 / 459
prostate	100%	10429.29	245 / 245	100%	45.63	501 / 502
skin	100%	7035.79	1808 / 1809	100%	39.41	471 / 472
breast	100%	6924.48	459 / 459	100%	34.34	1115 / 1118
intestine	100%	9272.04	966 / 966	100%	34.80	525 / 527
liver	100%	3780.50	226 / 226	100%	21.64	404 / 406
lung	100%	6472.07	577 / 578	100%	32.67	1151 / 1155
kidney	100%	6340.25	89 / 89	99%	26.84	896 / 901
brain	99%	6273.37	2626 / 2642	100%	38.61	705 / 705
stomach	100%	6474.65	359 / 359	99%	30.62	284 / 286
bladder	100%	10677.62	21 / 21	99%	41.30	500 / 504
adrenal gland	100%	6141.54	258 / 258	99%	25.19	228 / 230
adipose	100%	6157.08	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	34.68	80 / 80
lymph node	0%	0	0 / 0	100%	42.21	29 / 29
muscle	100%	6237.46	803 / 803	0%	0	0 / 0
spleen	100%	8065.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.92	45 / 45
ureter	0%	0	0 / 0	100%	40.58	1 / 1
blood vessel	100%	9086.89	1334 / 1335	0%	0	0 / 0
heart	99%	4654.75	854 / 861	0%	0	0 / 0
peripheral blood	95%	3940.15	885 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034243	Biological process	regulation of transcription elongation by RNA polymerase II
GO_0016180	Biological process	snRNA processing
GO_0072562	Cellular component	blood microparticle
GO_0032039	Cellular component	integrator complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004521	Molecular function	RNA endonuclease activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	INTS11
Protein name	Integrator complex subunit 11 Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) Cleavage and polyadenylation specific factor 3-like, isoform CRA_g (Integrator complex subunit 11) Cleavage and polyadenylation-specific factor 3-like protein
Synonyms	RC68 hCG_20422 CPSF3L
Description	FUNCTION: Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex . .
Accessions	ENST00000498476.6 ENST00000470679.3 E9PKA4 C9IYS7 ENST00000526797.5 E9PNH9 ENST00000450926.6 [Q5TA45-3] ENST00000435064.6 [Q5TA45-1] ENST00000458452.7 ENST00000526332.5 ENST00000419704.5 [Q5TA45-2] H0YDB1 ENST00000528879.5 E9PI75 E9PJG0 J3QRY6 E9PIG1 H0YE15 E9PNS4 ENST00000530031.5 ENST00000430786.5 A0A087WXT8 E9PQF0 ENST00000434694.6 ENST00000527719.5 ENST00000527098.5 ENST00000534345.5 ENST00000620829.4 E9PIL7 E9PIX9 C9J979 Q5TA45 ENST00000532772.5 ENST00000531377.5 H0YEQ9 ENST00000421495.6 H7C247 E9PMA2 E9PIS0 ENST00000531019.5 ENST00000411962.5 ENST00000525285.1 A0A087WYI0 ENST00000429572.5 ENST00000545578.5 [Q5TA45-4] ENST00000540437.5 [Q5TA45-5] Q96HV7

INTS11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review