INO80 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0045995Biological processregulation of embryonic development
GO_0030307Biological processpositive regulation of cell growth
GO_0034644Biological processcellular response to UV
GO_0000070Biological processmitotic sister chromatid segregation
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0070914Biological processUV-damage excision repair
GO_0006282Biological processregulation of DNA repair
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0060382Biological processregulation of DNA strand elongation
GO_1904507Biological processpositive regulation of telomere maintenance in response to DNA damage
GO_0051301Biological processcell division
GO_0006338Biological processchromatin remodeling
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006351Biological processDNA-templated transcription
GO_0010571Biological processpositive regulation of nuclear cell cycle DNA replication
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051225Biological processspindle assembly
GO_0000723Biological processtelomere maintenance
GO_0033044Biological processregulation of chromosome organization
GO_0071479Biological processcellular response to ionizing radiation
GO_0006275Biological processregulation of DNA replication
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005874Cellular componentmicrotubule
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0031011Cellular componentIno80 complex
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0005524Molecular functionATP binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameINO80
Protein nameChromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A)
INO80 complex ATPase subunit
Chromatin-remodeling ATPase INO80 (EC 3.6.4.-)
SynonymsINOC1
KIAA1259
INO80A
DescriptionFUNCTION: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair . Binds DNA . As part of the INO80 complex, remodels chromatin by shifting nucleosomes . Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle . .

FUNCTION: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. .

FUNCTION: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. .

FUNCTION: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. .

AccessionsH0YNL3
ENST00000557849.1
ENST00000559995.2
ENST00000648947.1
H0YKH3
ENST00000696949.1
ENST00000558357.6
Q9ULG1
A0A8V8TLQ3
H0YMN5