INAVA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INAVA at tissue level.

III. Associated gene sets

GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0034334Biological processadherens junction maintenance
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0032495Biological processresponse to muramyl dipeptide
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0032494Biological processresponse to peptidoglycan
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_1903409Biological processreactive oxygen species biosynthetic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0060729Biological processintestinal epithelial structure maintenance
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINAVA
Protein nameAlternative protein C1orf106
Innate immunity activator
Innate immunity activator protein
SynonymsC1orf106
DescriptionFUNCTION: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion . In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation . .

AccessionsENST00000532631.5
Q3KP66
A0A8V8N8P9
C9JAT8
ENST00000413687.3 [Q3KP66-3]
ENST00000367342.8
ENST00000451872.6
L8E8V8
E9PK29