ILRUN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0032480Biological processnegative regulation of type I interferon production
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0016236Biological processmacroautophagy
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0050687Biological processnegative regulation of defense response to virus
GO_0043392Biological processnegative regulation of DNA binding
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameILRUN
Protein nameProtein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein)
Alternative protein C6orf106
Inflammation and lipid regulator with UBA-like and NBR1-like domains
SynonymsC6orf106
DescriptionFUNCTION: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF . Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP . .

AccessionsQ5TH58
ENST00000374023.8 [Q9H6K1-1]
L8EB61
ENST00000374026.7 [Q9H6K1-2]
ENST00000374021.1
Q9H6K1