HTRA2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTRA2 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0007628Biological processadult walking behavior
GO_0045786Biological processnegative regulation of cell cycle
GO_0034605Biological processcellular response to heat
GO_0035694Biological processmitochondrial protein catabolic process
GO_0012501Biological processprogrammed cell death
GO_0030900Biological processforebrain development
GO_0016540Biological processprotein autoprocessing
GO_0006672Biological processceramide metabolic process
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0040014Biological processregulation of multicellular organism growth
GO_0071363Biological processcellular response to growth factor stimulus
GO_0019742Biological processpentacyclic triterpenoid metabolic process
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1903146Biological processregulation of autophagy of mitochondrion
GO_0035458Biological processcellular response to interferon-beta
GO_0051402Biological processneuron apoptotic process
GO_0034599Biological processcellular response to oxidative stress
GO_0007005Biological processmitochondrion organization
GO_0035556Biological processintracellular signal transduction
GO_0048666Biological processneuron development
GO_0006508Biological processproteolysis
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0009635Biological processresponse to herbicide
GO_0030163Biological processprotein catabolic process
GO_0097194Biological processexecution phase of apoptosis
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_2001241Biological processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_1904924Biological processnegative regulation of mitophagy in response to mitochondrial depolarization
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0005856Cellular componentcytoskeleton
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0035631Cellular componentCD40 receptor complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_1990948Molecular functionubiquitin ligase inhibitor activity
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0051082Molecular functionunfolded protein binding
GO_0008236Molecular functionserine-type peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameHTRA2
Protein nameMitochondrial serine protease
Epididymis secretory sperm binding protein (HtrA serine peptidase 2, isoform CRA_e)
Serine protease HTRA2, mitochondrial
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
HtrA serine peptidase 2
SynonymshCG_41061
OMI
PRSS25
DescriptionFUNCTION: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. .

AccessionsENST00000437202.1
ENST00000696727.1
O43464
ENST00000352222.7 [O43464-2]
ENST00000696728.1
ENST00000258080.8 [O43464-1]
ENST00000437202.2 [O43464-3]
A0A0C4DG44
A0A384MDW9
B2BKJ3
A0A8Q3SJ36
A0A8Q3SIX7