HMOX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	37 studies	46% ± 18%	Explore
non-classical monocyte	23 studies	60% ± 15%	Explore
classical monocyte	22 studies	34% ± 14%	Explore
monocyte	17 studies	29% ± 10%	Explore
conventional dendritic cell	15 studies	27% ± 12%	Explore
myeloid cell	12 studies	34% ± 12%	Explore
dendritic cell	11 studies	28% ± 11%	Explore
fibroblast	7 studies	27% ± 9%	Explore
alveolar macrophage	6 studies	31% ± 8%	Explore
endothelial cell of vascular tree	5 studies	51% ± 17%	Explore
leukocyte	4 studies	22% ± 5%	Explore
endothelial cell	4 studies	26% ± 14%	Explore
microglial cell	4 studies	25% ± 5%	Explore
mononuclear phagocyte	4 studies	37% ± 11%	Explore
inflammatory macrophage	4 studies	37% ± 10%	Explore
intermediate monocyte	4 studies	53% ± 16%	Explore
squamous epithelial cell	3 studies	40% ± 11%	Explore
epithelial cell of proximal tubule	3 studies	24% ± 9%	Explore
epithelial cell	3 studies	27% ± 1%	Explore
tissue-resident macrophage	3 studies	45% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	19% ± 2%	Explore
kidney	3 studies	21% ± 4%	Explore
placenta	3 studies	30% ± 14%	Explore
lung	3 studies	24% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	98%	6228.12	1764 / 1809	92%	114.35	433 / 472
lung	96%	9949.40	554 / 578	91%	95.98	1046 / 1155
kidney	90%	6790.48	80 / 89	93%	344.23	842 / 901
ovary	96%	7241.84	172 / 180	70%	37.12	302 / 430
adrenal gland	88%	3950.90	226 / 258	73%	100.92	169 / 230
liver	79%	4523.79	179 / 226	82%	79.18	332 / 406
breast	59%	1537.75	271 / 459	94%	80.28	1051 / 1118
bladder	62%	1705.67	13 / 21	81%	80.78	407 / 504
intestine	65%	1901.20	627 / 966	72%	38.88	379 / 527
uterus	34%	648.61	57 / 170	84%	76.00	386 / 459
brain	27%	537.37	716 / 2642	88%	118.90	623 / 705
thymus	38%	721.03	245 / 653	77%	48.51	468 / 605
esophagus	52%	1514.49	752 / 1445	59%	28.10	108 / 183
stomach	32%	1176.42	115 / 359	76%	41.80	218 / 286
lymph node	0%	0	0 / 0	100%	193.80	29 / 29
spleen	100%	49307.53	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	25.47	1 / 1
peripheral blood	97%	7506.44	898 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	50.66	43 / 45
pancreas	5%	97.77	18 / 328	86%	59.30	153 / 178
adipose	91%	6100.12	1091 / 1204	0%	0	0 / 0
muscle	67%	4818.94	542 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	57%	32.53	46 / 80
blood vessel	51%	1527.90	687 / 1335	0%	0	0 / 0
prostate	15%	302.53	37 / 245	12%	4.66	60 / 502
heart	21%	598.28	180 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_0032722	Biological process	positive regulation of chemokine production
GO_0001525	Biological process	angiogenesis
GO_0002686	Biological process	negative regulation of leukocyte migration
GO_0016242	Biological process	negative regulation of macroautophagy
GO_0034605	Biological process	cellular response to heat
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0110076	Biological process	negative regulation of ferroptosis
GO_0071276	Biological process	cellular response to cadmium ion
GO_0016236	Biological process	macroautophagy
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0042167	Biological process	heme catabolic process
GO_1904037	Biological process	positive regulation of epithelial cell apoptotic process
GO_0045765	Biological process	regulation of angiogenesis
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0034101	Biological process	erythrocyte homeostasis
GO_0014806	Biological process	smooth muscle hyperplasia
GO_0035556	Biological process	intracellular signal transduction
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0006788	Biological process	heme oxidation
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0001935	Biological process	endothelial cell proliferation
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0035094	Biological process	response to nicotine
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0048662	Biological process	negative regulation of smooth muscle cell proliferation
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0002246	Biological process	wound healing involved in inflammatory response
GO_1902042	Biological process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0006979	Biological process	response to oxidative stress
GO_1903589	Biological process	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0071243	Biological process	cellular response to arsenic-containing substance
GO_0072719	Biological process	cellular response to cisplatin
GO_0005615	Cellular component	extracellular space
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0004392	Molecular function	heme oxygenase (decyclizing) activity
GO_0042802	Molecular function	identical protein binding
GO_0005198	Molecular function	structural molecule activity
GO_0020037	Molecular function	heme binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HMOX1
Protein name	Heme oxygenase (EC 1.14.14.18) Heme oxygenase 1 (EC 1.14.14.18) Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] Heme oxygenase 1
Synonyms	HO1 HO hCG_40033
Description	FUNCTION: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron . Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis . .; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. .; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. . FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. .
Accessions	A0A7I2YQL9 Q6FH11 ENST00000678411.1 P09601 A0A7I2V3M0 ENST00000481190.2 D2K7W4 F2YMD9 A0A7I2V3I1 ENST00000412893.5 ENST00000677931.1 B1AHA8 ENST00000679074.1 Q96DI8 ENST00000216117.9 A0A7I2V277

HMOX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review