HMGB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032392Biological processDNA geometric change
GO_0006310Biological processDNA recombination
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005694Cellular componentchromosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0008301Molecular functionDNA binding, bending
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHMGB3
Protein nameHigh mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)
High mobility group box 3
SynonymsHMG2A
HMG4
DescriptionFUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). .

AccessionsE7ES08
ENST00000448905.6
ENST00000419110.5
ENST00000325307.12
E7EQU1
O15347
ENST00000430118.1
E9PES6
ENST00000455596.5