Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 9 studies | 37% ± 18% | |
| epithelial cell | 8 studies | 38% ± 18% | |
| B cell | 5 studies | 19% ± 3% | |
| plasmablast | 5 studies | 32% ± 17% | |
| club cell | 5 studies | 24% ± 7% | |
| ionocyte | 5 studies | 48% ± 18% | |
| endothelial cell | 5 studies | 24% ± 12% | |
| progenitor cell | 5 studies | 21% ± 5% | |
| erythroblast | 5 studies | 32% ± 19% | |
| neuron | 5 studies | 24% ± 12% | |
| secretory cell | 4 studies | 32% ± 21% | |
| pancreatic A cell | 4 studies | 33% ± 11% | |
| hematopoietic precursor cell | 4 studies | 25% ± 8% | |
| transit amplifying cell | 4 studies | 23% ± 5% | |
| pro-B cell | 4 studies | 23% ± 4% | |
| ciliated cell | 4 studies | 41% ± 17% | |
| erythrocyte | 4 studies | 29% ± 16% | |
| deuterosomal cell | 3 studies | 32% ± 4% | |
| myofibroblast cell | 3 studies | 17% ± 1% | |
| connective tissue cell | 3 studies | 30% ± 12% | |
| fibroblast | 3 studies | 17% ± 1% | |
| neural crest cell | 3 studies | 47% ± 13% | |
| pericyte | 3 studies | 20% ± 2% | |
| smooth muscle cell | 3 studies | 23% ± 6% | |
| extravillous trophoblast | 3 studies | 76% ± 10% | |
| placental villous trophoblast | 3 studies | 79% ± 3% | |
| dendritic cell | 3 studies | 24% ± 4% | |
| enteroendocrine cell | 3 studies | 24% ± 9% | |
| intestinal crypt stem cell | 3 studies | 22% ± 3% | |
| precursor B cell | 3 studies | 42% ± 13% | |
| CD4-positive, alpha-beta T cell | 3 studies | 25% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 961.38 | 565 / 578 | 97% | 166.83 | 1118 / 1155 |
| brain | 97% | 1018.41 | 2558 / 2642 | 96% | 43.98 | 677 / 705 |
| prostate | 96% | 752.96 | 235 / 245 | 95% | 30.19 | 478 / 502 |
| breast | 95% | 500.68 | 435 / 459 | 95% | 77.08 | 1064 / 1118 |
| intestine | 92% | 1042.22 | 886 / 966 | 96% | 57.94 | 507 / 527 |
| liver | 100% | 3484.80 | 226 / 226 | 85% | 43.44 | 344 / 406 |
| esophagus | 88% | 716.06 | 1267 / 1445 | 93% | 52.43 | 171 / 183 |
| stomach | 86% | 514.75 | 309 / 359 | 92% | 50.18 | 263 / 286 |
| pancreas | 92% | 576.79 | 303 / 328 | 85% | 30.57 | 152 / 178 |
| bladder | 76% | 463.05 | 16 / 21 | 99% | 94.69 | 500 / 504 |
| skin | 100% | 1536.74 | 1806 / 1809 | 74% | 26.20 | 350 / 472 |
| thymus | 99% | 878.03 | 649 / 653 | 69% | 24.39 | 419 / 605 |
| uterus | 66% | 338.90 | 113 / 170 | 98% | 108.16 | 452 / 459 |
| ovary | 68% | 321.76 | 122 / 180 | 96% | 47.15 | 412 / 430 |
| kidney | 100% | 968.56 | 89 / 89 | 50% | 20.59 | 447 / 901 |
| adrenal gland | 100% | 837.95 | 257 / 258 | 31% | 12.19 | 71 / 230 |
| spleen | 100% | 1247.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 74.14 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 53.54 | 1 / 1 |
| muscle | 93% | 1994.44 | 746 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 37.47 | 26 / 29 |
| adipose | 86% | 399.52 | 1034 / 1204 | 0% | 0 | 0 / 0 |
| heart | 69% | 307.03 | 596 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 45% | 743.15 | 422 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 34% | 110.88 | 450 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 21% | 4.80 | 17 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032392 | Biological process | DNA geometric change |
| GO_0006310 | Biological process | DNA recombination |
| GO_0045087 | Biological process | innate immune response |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0005694 | Cellular component | chromosome |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003723 | Molecular function | RNA binding |
| GO_0000400 | Molecular function | four-way junction DNA binding |
| GO_0003690 | Molecular function | double-stranded DNA binding |
| GO_0008301 | Molecular function | DNA binding, bending |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HMGB3 |
| Protein name | High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) High mobility group box 3 |
| Synonyms | HMG2A HMG4 |
| Description | FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). . |
| Accessions | E7ES08 ENST00000448905.6 ENST00000419110.5 ENST00000325307.12 E7EQU1 O15347 ENST00000430118.1 E9PES6 ENST00000455596.5 |