HLTF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0006338Biological processchromatin remodeling
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0050767Biological processregulation of neurogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004386Molecular functionhelicase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0016818Molecular functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHLTF
Protein nameHelicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Helicase like transcription factor (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3, isoform CRA_c)
HLTF protein
Helicase like transcription factor
SynonymshCG_21212
ZBU1
SMARCA3
SNF2L3
RNF80
HIP116A
DescriptionFUNCTION: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. .

AccessionsENST00000494055.5 [Q14527-1]
ENST00000467858.1
ENST00000310053.10 [Q14527-1]
A0A0C4DGA6
Q05DQ5
H7C5K0
Q05BZ6
Q14527
ENST00000465259.5
ENST00000392912.6 [Q14527-1]
Q05DF7