Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 10 studies | 30% ± 12% | |
GABAergic neuron | 9 studies | 40% ± 20% | |
oligodendrocyte precursor cell | 9 studies | 30% ± 12% | |
interneuron | 7 studies | 41% ± 21% | |
glutamatergic neuron | 7 studies | 43% ± 24% | |
endothelial cell | 6 studies | 30% ± 14% | |
fibroblast | 6 studies | 17% ± 2% | |
oligodendrocyte | 6 studies | 29% ± 7% | |
neuron | 5 studies | 32% ± 11% | |
retinal bipolar neuron | 5 studies | 28% ± 6% | |
retinal cone cell | 5 studies | 29% ± 6% | |
mast cell | 4 studies | 22% ± 6% | |
granule cell | 4 studies | 22% ± 6% | |
epithelial cell | 4 studies | 21% ± 6% | |
retina horizontal cell | 4 studies | 20% ± 4% | |
GABAergic interneuron | 3 studies | 27% ± 9% | |
microglial cell | 3 studies | 24% ± 5% | |
amacrine cell | 3 studies | 18% ± 4% | |
ciliated cell | 3 studies | 24% ± 7% | |
OFF-bipolar cell | 3 studies | 26% ± 5% | |
ON-bipolar cell | 3 studies | 26% ± 5% | |
retinal rod cell | 3 studies | 20% ± 3% | |
rod bipolar cell | 3 studies | 45% ± 8% | |
neural progenitor cell | 3 studies | 23% ± 5% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 38% ± 11% | |
plasmacytoid dendritic cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2939.73 | 2635 / 2642 | 98% | 19.36 | 688 / 705 |
breast | 100% | 1598.46 | 458 / 459 | 95% | 23.78 | 1059 / 1118 |
esophagus | 97% | 1461.72 | 1407 / 1445 | 95% | 21.14 | 174 / 183 |
ovary | 100% | 2552.14 | 180 / 180 | 92% | 13.09 | 394 / 430 |
lung | 95% | 1119.17 | 548 / 578 | 95% | 15.77 | 1098 / 1155 |
prostate | 100% | 1823.70 | 244 / 245 | 89% | 16.42 | 446 / 502 |
pancreas | 99% | 1061.65 | 325 / 328 | 89% | 7.98 | 158 / 178 |
uterus | 100% | 2379.68 | 170 / 170 | 85% | 16.01 | 392 / 459 |
thymus | 100% | 2426.86 | 653 / 653 | 84% | 11.39 | 511 / 605 |
kidney | 99% | 1281.66 | 88 / 89 | 82% | 9.60 | 740 / 901 |
bladder | 100% | 1869.95 | 21 / 21 | 80% | 9.96 | 402 / 504 |
stomach | 100% | 1379.86 | 359 / 359 | 78% | 8.61 | 222 / 286 |
skin | 89% | 1469.46 | 1619 / 1809 | 88% | 16.82 | 415 / 472 |
adrenal gland | 100% | 4019.88 | 258 / 258 | 77% | 9.97 | 178 / 230 |
intestine | 99% | 1972.00 | 959 / 966 | 73% | 7.20 | 384 / 527 |
liver | 97% | 929.56 | 219 / 226 | 66% | 6.18 | 267 / 406 |
spleen | 100% | 1302.06 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 1568.08 | 1199 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2170.07 | 1328 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 1445.50 | 819 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 25.52 | 39 / 45 |
muscle | 87% | 748.42 | 695 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 52% | 5.99 | 15 / 29 |
eye | 0% | 0 | 0 / 0 | 40% | 2.50 | 32 / 80 |
peripheral blood | 35% | 1217.89 | 326 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006281 | Biological process | DNA repair |
GO_0006338 | Biological process | chromatin remodeling |
GO_0042789 | Biological process | mRNA transcription by RNA polymerase II |
GO_0050767 | Biological process | regulation of neurogenesis |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005730 | Cellular component | nucleolus |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016363 | Cellular component | nuclear matrix |
GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004386 | Molecular function | helicase activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0016818 | Molecular function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0008094 | Molecular function | ATP-dependent activity, acting on DNA |
GO_0005515 | Molecular function | protein binding |
Gene name | HLTF |
Protein name | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) Helicase like transcription factor (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3, isoform CRA_c) HLTF protein Helicase like transcription factor |
Synonyms | hCG_21212 ZBU1 SMARCA3 SNF2L3 RNF80 HIP116A |
Description | FUNCTION: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. . |
Accessions | ENST00000494055.5 [Q14527-1] ENST00000467858.1 ENST00000310053.10 [Q14527-1] A0A0C4DGA6 Q05DQ5 H7C5K0 Q05BZ6 Q14527 ENST00000465259.5 ENST00000392912.6 [Q14527-1] Q05DF7 |