HLCS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006768Biological processbiotin metabolic process
GO_0043687Biological processpost-translational protein modification
GO_0070781Biological processresponse to biotin
GO_0005739Cellular componentmitochondrion
GO_0016363Cellular componentnuclear matrix
GO_0005652Cellular componentnuclear lamina
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0019899Molecular functionenzyme binding
GO_0004079Molecular functionbiotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0018271Molecular functionbiotin-protein ligase activity
GO_0004078Molecular functionbiotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO_0004080Molecular functionbiotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO_0005524Molecular functionATP binding
GO_0009374Molecular functionbiotin binding
GO_0005515Molecular functionprotein binding
GO_0004077Molecular functionbiotin-[acetyl-CoA-carboxylase] ligase activity

IV. Literature review

[source]
Gene nameHLCS
Protein nameBiotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]
Biotin--protein ligase
Holocarboxylase synthetase
Synonyms
DescriptionFUNCTION: Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. .

AccessionsENST00000336648.8 [P50747-1]
A0A0C4DG27
ENST00000675057.1
ENST00000612277.4 [P50747-1]
ENST00000399120.5 [P50747-1]
A0A6Q8PFK4
C9JCQ9
ENST00000448340.5
ENST00000675307.1 [P50747-1]
ENST00000674895
ENST00000427746.1
ENST00000674895.3 [P50747-2]
A0A8C8QSB1
P50747