Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 31% ± 14% | |
oligodendrocyte | 11 studies | 26% ± 9% | |
glutamatergic neuron | 10 studies | 41% ± 23% | |
GABAergic neuron | 9 studies | 41% ± 24% | |
endothelial cell | 9 studies | 28% ± 10% | |
adipocyte | 9 studies | 32% ± 8% | |
oligodendrocyte precursor cell | 9 studies | 33% ± 12% | |
macrophage | 7 studies | 22% ± 5% | |
fibroblast | 7 studies | 21% ± 5% | |
neuron | 5 studies | 24% ± 11% | |
microglial cell | 5 studies | 23% ± 3% | |
type I pneumocyte | 5 studies | 23% ± 4% | |
type II pneumocyte | 5 studies | 25% ± 5% | |
interneuron | 5 studies | 48% ± 27% | |
epithelial cell | 4 studies | 31% ± 13% | |
retinal cone cell | 4 studies | 17% ± 1% | |
club cell | 4 studies | 26% ± 8% | |
smooth muscle cell | 4 studies | 18% ± 2% | |
GABAergic interneuron | 3 studies | 31% ± 3% | |
retina horizontal cell | 3 studies | 17% ± 0% | |
hepatocyte | 3 studies | 52% ± 23% | |
retinal pigment epithelial cell | 3 studies | 49% ± 14% | |
retinal rod cell | 3 studies | 20% ± 2% | |
ependymal cell | 3 studies | 27% ± 13% | |
ciliated cell | 3 studies | 21% ± 4% | |
respiratory goblet cell | 3 studies | 31% ± 16% | |
lymphocyte | 3 studies | 22% ± 4% | |
basal cell | 3 studies | 31% ± 14% | |
pericyte | 3 studies | 20% ± 6% | |
granule cell | 3 studies | 39% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1868.44 | 245 / 245 | 100% | 30.21 | 502 / 502 |
breast | 100% | 1214.80 | 459 / 459 | 100% | 17.07 | 1115 / 1118 |
bladder | 100% | 1271.52 | 21 / 21 | 99% | 10.41 | 498 / 504 |
intestine | 100% | 986.95 | 966 / 966 | 99% | 9.32 | 520 / 527 |
pancreas | 100% | 1132.03 | 328 / 328 | 98% | 8.51 | 175 / 178 |
uterus | 100% | 913.66 | 170 / 170 | 98% | 10.92 | 451 / 459 |
brain | 100% | 1156.58 | 2637 / 2642 | 98% | 8.75 | 694 / 705 |
lung | 100% | 1059.16 | 576 / 578 | 98% | 9.31 | 1135 / 1155 |
stomach | 100% | 1056.20 | 359 / 359 | 97% | 9.12 | 278 / 286 |
esophagus | 100% | 1139.86 | 1444 / 1445 | 97% | 9.65 | 178 / 183 |
thymus | 100% | 1619.06 | 653 / 653 | 97% | 9.97 | 588 / 605 |
kidney | 100% | 1163.19 | 89 / 89 | 93% | 7.92 | 841 / 901 |
ovary | 100% | 742.39 | 180 / 180 | 93% | 7.72 | 401 / 430 |
skin | 99% | 1213.68 | 1799 / 1809 | 93% | 9.08 | 437 / 472 |
liver | 100% | 1306.27 | 226 / 226 | 90% | 6.40 | 364 / 406 |
adrenal gland | 100% | 1449.99 | 258 / 258 | 88% | 8.32 | 202 / 230 |
adipose | 100% | 965.47 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1299.91 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 777.62 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.08 | 1 / 1 |
muscle | 100% | 1035.05 | 801 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 12.99 | 44 / 45 |
heart | 92% | 526.26 | 795 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 4.76 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 78% | 5.24 | 62 / 80 |
peripheral blood | 54% | 348.30 | 500 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006768 | Biological process | biotin metabolic process |
GO_0043687 | Biological process | post-translational protein modification |
GO_0070781 | Biological process | response to biotin |
GO_0005739 | Cellular component | mitochondrion |
GO_0016363 | Cellular component | nuclear matrix |
GO_0005652 | Cellular component | nuclear lamina |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0019899 | Molecular function | enzyme binding |
GO_0004079 | Molecular function | biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0018271 | Molecular function | biotin-protein ligase activity |
GO_0004078 | Molecular function | biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity |
GO_0004080 | Molecular function | biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0009374 | Molecular function | biotin binding |
GO_0005515 | Molecular function | protein binding |
GO_0004077 | Molecular function | biotin-[acetyl-CoA-carboxylase] ligase activity |
Gene name | HLCS |
Protein name | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] Biotin--protein ligase Holocarboxylase synthetase |
Synonyms | |
Description | FUNCTION: Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. . |
Accessions | ENST00000336648.8 [P50747-1] A0A0C4DG27 ENST00000675057.1 ENST00000612277.4 [P50747-1] ENST00000399120.5 [P50747-1] A0A6Q8PFK4 C9JCQ9 ENST00000448340.5 ENST00000675307.1 [P50747-1] ENST00000674895 ENST00000427746.1 ENST00000674895.3 [P50747-2] A0A8C8QSB1 P50747 |