HEXB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0043615Biological processastrocyte cell migration
GO_0007605Biological processsensory perception of sound
GO_0008049Biological processmale courtship behavior
GO_0030207Biological processchondroitin sulfate catabolic process
GO_0042552Biological processmyelination
GO_0050885Biological processneuromuscular process controlling balance
GO_0030209Biological processdermatan sulfate catabolic process
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0030214Biological processhyaluronan catabolic process
GO_0051651Biological processmaintenance of location in cell
GO_0030203Biological processglycosaminoglycan metabolic process
GO_0070050Biological processneuron cellular homeostasis
GO_0008654Biological processphospholipid biosynthetic process
GO_0019915Biological processlipid storage
GO_0001501Biological processskeletal system development
GO_0008360Biological processregulation of cell shape
GO_0007338Biological processsingle fertilization
GO_0009313Biological processoligosaccharide catabolic process
GO_0048477Biological processoogenesis
GO_0007626Biological processlocomotory behavior
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006689Biological processganglioside catabolic process
GO_0007341Biological processpenetration of zona pellucida
GO_0035578Cellular componentazurophil granule lumen
GO_0001669Cellular componentacrosomal vesicle
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_1905379Cellular componentbeta-N-acetylhexosaminidase complex
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0042582Cellular componentazurophil granule
GO_0060473Cellular componentcortical granule
GO_0043202Cellular componentlysosomal lumen
GO_0004563Molecular functionbeta-N-acetylhexosaminidase activity
GO_0042802Molecular functionidentical protein binding
GO_0102148Molecular functionN-acetyl-beta-D-galactosaminidase activity
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHEXB
Protein nameBeta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (N-acetyl-beta-glucosaminidase subunit beta)
Beta-hexosaminidase (EC 3.2.1.52)
Hexosaminidase subunit beta
SynonymsHCC7
HEL-248
HEL-S-111
hCG_38198
DescriptionFUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides . The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide . Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A . During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). .

AccessionsP07686
ENST00000505859.1
ENST00000513336.5
H0YA83
ENST00000511181.5
D6REQ8
ENST00000503312.5
ENST00000509579.1
H0Y9B6
Q5URX0
H0Y9M3
ENST00000261416.12
A0A024RAJ6