Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 34 studies | 36% ± 14% | |
classical monocyte | 23 studies | 29% ± 10% | |
conventional dendritic cell | 19 studies | 31% ± 14% | |
fibroblast | 18 studies | 28% ± 11% | |
monocyte | 17 studies | 26% ± 8% | |
endothelial cell | 16 studies | 23% ± 7% | |
dendritic cell | 11 studies | 35% ± 17% | |
plasmacytoid dendritic cell | 10 studies | 24% ± 8% | |
myeloid cell | 10 studies | 36% ± 9% | |
endothelial cell of lymphatic vessel | 9 studies | 23% ± 10% | |
alveolar macrophage | 8 studies | 55% ± 20% | |
non-classical monocyte | 7 studies | 23% ± 6% | |
plasma cell | 7 studies | 25% ± 9% | |
myofibroblast cell | 7 studies | 21% ± 9% | |
epithelial cell | 7 studies | 38% ± 17% | |
basal cell | 7 studies | 24% ± 6% | |
mononuclear phagocyte | 6 studies | 31% ± 9% | |
capillary endothelial cell | 6 studies | 17% ± 2% | |
connective tissue cell | 6 studies | 22% ± 5% | |
pericyte | 5 studies | 23% ± 5% | |
endothelial cell of vascular tree | 5 studies | 20% ± 2% | |
secretory cell | 4 studies | 20% ± 4% | |
pancreatic A cell | 4 studies | 33% ± 18% | |
abnormal cell | 4 studies | 22% ± 3% | |
smooth muscle cell | 4 studies | 19% ± 4% | |
microglial cell | 4 studies | 25% ± 6% | |
adventitial cell | 4 studies | 26% ± 12% | |
ciliated cell | 4 studies | 21% ± 4% | |
glutamatergic neuron | 4 studies | 43% ± 17% | |
type B pancreatic cell | 3 studies | 40% ± 20% | |
hematopoietic precursor cell | 3 studies | 24% ± 8% | |
extravillous trophoblast | 3 studies | 35% ± 11% | |
placental villous trophoblast | 3 studies | 62% ± 13% | |
astrocyte | 3 studies | 30% ± 4% | |
tissue-resident macrophage | 3 studies | 32% ± 9% | |
intermediate monocyte | 3 studies | 34% ± 13% | |
GABAergic neuron | 3 studies | 42% ± 1% | |
pancreatic ductal cell | 3 studies | 67% ± 17% | |
enterocyte | 3 studies | 20% ± 2% | |
goblet cell | 3 studies | 23% ± 3% | |
intestinal crypt stem cell | 3 studies | 20% ± 2% | |
leukocyte | 3 studies | 22% ± 5% | |
mast cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 7028.65 | 578 / 578 | 100% | 78.50 | 1155 / 1155 |
pancreas | 100% | 3641.57 | 328 / 328 | 100% | 91.89 | 178 / 178 |
stomach | 100% | 3758.70 | 359 / 359 | 100% | 91.38 | 286 / 286 |
breast | 100% | 5731.61 | 459 / 459 | 100% | 84.90 | 1115 / 1118 |
intestine | 100% | 4847.91 | 966 / 966 | 100% | 100.02 | 525 / 527 |
uterus | 100% | 4945.52 | 170 / 170 | 100% | 69.28 | 457 / 459 |
skin | 100% | 4919.71 | 1808 / 1809 | 100% | 118.55 | 470 / 472 |
thymus | 100% | 5555.93 | 653 / 653 | 100% | 93.06 | 602 / 605 |
esophagus | 100% | 3168.42 | 1442 / 1445 | 99% | 50.58 | 182 / 183 |
liver | 99% | 2987.59 | 224 / 226 | 100% | 83.48 | 406 / 406 |
kidney | 100% | 4114.45 | 89 / 89 | 99% | 78.22 | 892 / 901 |
bladder | 100% | 4462.71 | 21 / 21 | 99% | 77.10 | 498 / 504 |
prostate | 100% | 3844.51 | 244 / 245 | 99% | 107.34 | 498 / 502 |
ovary | 100% | 3973.20 | 180 / 180 | 97% | 36.30 | 417 / 430 |
adrenal gland | 100% | 4512.16 | 258 / 258 | 95% | 59.05 | 219 / 230 |
brain | 88% | 1408.06 | 2322 / 2642 | 93% | 37.63 | 654 / 705 |
adipose | 100% | 5980.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5809.14 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 58.74 | 29 / 29 |
spleen | 100% | 3685.82 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 58.01 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.56 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 95.37 | 79 / 80 |
heart | 98% | 3346.10 | 843 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 3288.16 | 900 / 929 | 0% | 0 | 0 / 0 |
muscle | 94% | 1760.14 | 752 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007040 | Biological process | lysosome organization |
GO_0043615 | Biological process | astrocyte cell migration |
GO_0007605 | Biological process | sensory perception of sound |
GO_0008049 | Biological process | male courtship behavior |
GO_0030207 | Biological process | chondroitin sulfate catabolic process |
GO_0042552 | Biological process | myelination |
GO_0050885 | Biological process | neuromuscular process controlling balance |
GO_0030209 | Biological process | dermatan sulfate catabolic process |
GO_0006874 | Biological process | intracellular calcium ion homeostasis |
GO_0030214 | Biological process | hyaluronan catabolic process |
GO_0051651 | Biological process | maintenance of location in cell |
GO_0030203 | Biological process | glycosaminoglycan metabolic process |
GO_0070050 | Biological process | neuron cellular homeostasis |
GO_0008654 | Biological process | phospholipid biosynthetic process |
GO_0019915 | Biological process | lipid storage |
GO_0001501 | Biological process | skeletal system development |
GO_0008360 | Biological process | regulation of cell shape |
GO_0007338 | Biological process | single fertilization |
GO_0009313 | Biological process | oligosaccharide catabolic process |
GO_0048477 | Biological process | oogenesis |
GO_0007626 | Biological process | locomotory behavior |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0006689 | Biological process | ganglioside catabolic process |
GO_0007341 | Biological process | penetration of zona pellucida |
GO_0035578 | Cellular component | azurophil granule lumen |
GO_0001669 | Cellular component | acrosomal vesicle |
GO_0005576 | Cellular component | extracellular region |
GO_0016020 | Cellular component | membrane |
GO_1905379 | Cellular component | beta-N-acetylhexosaminidase complex |
GO_0005764 | Cellular component | lysosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0042582 | Cellular component | azurophil granule |
GO_0060473 | Cellular component | cortical granule |
GO_0043202 | Cellular component | lysosomal lumen |
GO_0004563 | Molecular function | beta-N-acetylhexosaminidase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0102148 | Molecular function | N-acetyl-beta-D-galactosaminidase activity |
GO_0008375 | Molecular function | acetylglucosaminyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | HEXB |
Protein name | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (N-acetyl-beta-glucosaminidase subunit beta) Beta-hexosaminidase (EC 3.2.1.52) Hexosaminidase subunit beta |
Synonyms | HCC7 HEL-248 HEL-S-111 hCG_38198 |
Description | FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides . The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide . Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A . During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). . |
Accessions | P07686 ENST00000505859.1 ENST00000513336.5 H0YA83 ENST00000511181.5 D6REQ8 ENST00000503312.5 ENST00000509579.1 H0Y9B6 Q5URX0 H0Y9M3 ENST00000261416.12 A0A024RAJ6 |