GSAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030162Biological processregulation of proteolysis
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0005802Cellular componenttrans-Golgi network
GO_0001540Molecular functionamyloid-beta binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGSAP
Protein nameGamma-secretase activating protein (PION protein)
Gamma-secretase-activating protein (GSAP) (Protein pigeon homolog) [Cleaved into: Gamma-secretase-activating protein 16 kDa C-terminal form (GSAP-16K)]
Gamma-secretase activating protein
SynonymsPION
DescriptionFUNCTION: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. .

AccessionsH7C0Q7
ENST00000441833.6
A4D1B5
ENST00000415112.2
ENST00000257626.12 [A4D1B5-1]
B7ZL33