GRIK2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	15 studies	73% ± 22%	Explore
glutamatergic neuron	13 studies	75% ± 21%	Explore
GABAergic neuron	11 studies	71% ± 27%	Explore
oligodendrocyte	9 studies	35% ± 21%	Explore
microglial cell	8 studies	34% ± 22%	Explore
neuron	7 studies	43% ± 17%	Explore
endothelial cell	7 studies	39% ± 21%	Explore
interneuron	7 studies	59% ± 35%	Explore
astrocyte	7 studies	38% ± 24%	Explore
granule cell	4 studies	90% ± 5%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	60% ± 10%	Explore
GABAergic interneuron	3 studies	75% ± 29%	Explore
GABAergic amacrine cell	3 studies	54% ± 15%	Explore
amacrine cell	3 studies	87% ± 12%	Explore
glycinergic amacrine cell	3 studies	94% ± 7%	Explore
retinal ganglion cell	3 studies	67% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	48% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	3944.14	2606 / 2642	98%	26.75	689 / 705
thymus	61%	264.40	398 / 653	37%	1.80	225 / 605
prostate	71%	317.13	173 / 245	27%	0.49	135 / 502
adrenal gland	16%	87.95	42 / 258	67%	6.37	154 / 230
heart	62%	432.92	537 / 861	0%	0	0 / 0
skin	9%	29.24	168 / 1809	45%	3.07	213 / 472
esophagus	33%	157.63	471 / 1445	10%	0.31	19 / 183
kidney	38%	113.89	34 / 89	3%	0.09	24 / 901
intestine	35%	174.99	339 / 966	5%	0.12	24 / 527
muscle	37%	257.13	297 / 803	0%	0	0 / 0
bladder	29%	93.57	6 / 21	6%	0.16	30 / 504
lung	1%	1.56	3 / 578	24%	0.76	282 / 1155
uterus	8%	48.53	13 / 170	17%	0.56	77 / 459
pancreas	4%	10.67	14 / 328	19%	0.73	34 / 178
ovary	12%	48.51	22 / 180	10%	0.24	45 / 430
stomach	16%	85.32	57 / 359	3%	0.06	9 / 286
breast	5%	14.45	23 / 459	8%	0.22	84 / 1118
adipose	7%	34.90	88 / 1204	0%	0	0 / 0
blood vessel	7%	25.70	88 / 1335	0%	0	0 / 0
liver	0%	0	0 / 226	6%	0.21	23 / 406
eye	0%	0	0 / 0	4%	0.04	3 / 80
tonsil	0%	0	0 / 0	2%	0.04	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046328	Biological process	regulation of JNK cascade
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0048169	Biological process	regulation of long-term neuronal synaptic plasticity
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0035235	Biological process	ionotropic glutamate receptor signaling pathway
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0051967	Biological process	negative regulation of synaptic transmission, glutamatergic
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_0098815	Biological process	modulation of excitatory postsynaptic potential
GO_0043113	Biological process	receptor clustering
GO_0051402	Biological process	neuron apoptotic process
GO_0120169	Biological process	detection of cold stimulus involved in thermoception
GO_0007268	Biological process	chemical synaptic transmission
GO_0019228	Biological process	neuronal action potential
GO_0099171	Biological process	presynaptic modulation of chemical synaptic transmission
GO_0060080	Biological process	inhibitory postsynaptic potential
GO_0001662	Biological process	behavioral fear response
GO_0050806	Biological process	positive regulation of synaptic transmission
GO_0007215	Biological process	glutamate receptor signaling pathway
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0048172	Biological process	regulation of short-term neuronal synaptic plasticity
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0043204	Cellular component	perikaryon
GO_0043195	Cellular component	terminal bouton
GO_0098686	Cellular component	hippocampal mossy fiber to CA3 synapse
GO_0042734	Cellular component	presynaptic membrane
GO_0097471	Cellular component	mossy fiber rosette
GO_0032839	Cellular component	dendrite cytoplasm
GO_0032983	Cellular component	kainate selective glutamate receptor complex
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004970	Molecular function	glutamate-gated receptor activity
GO_0042802	Molecular function	identical protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0030165	Molecular function	PDZ domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0000149	Molecular function	SNARE binding
GO_0015277	Molecular function	kainate selective glutamate receptor activity
GO_0099507	Molecular function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005234	Molecular function	extracellularly glutamate-gated ion channel activity
GO_0031624	Molecular function	ubiquitin conjugating enzyme binding

IV. Literature review

[source]

Gene name	GRIK2
Protein name	Glutamate receptor GRIK2 protein Glutamate ionotropic receptor kainate type subunit 2 (Glutamate receptor, ionotropic, kainate 2, isoform CRA_b) Glutamate ionotropic receptor kainate type subunit 2 BA487F5.1 (Glutamate receptor, ionotropic, kainate 2) Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) Alternative protein GRIK2 Glutamate ionotropic receptor kainate type subunit 2 (Putative NMDtranscript(Cassette_171nt))
Synonyms	hCG_16784 GLUR6
Description	FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist . Modulates cell surface expression of NETO2 (By similarity). .; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures . Functions in dorsal root ganglion neurons (By similarity). . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .
Accessions	Q8IY40 ENST00000421544.6 [Q13002-1] ENST00000682222.1 Q6P3V6 ENST00000436862.2 L8E9A1 ENST00000683208.1 ENST00000369134.9 [Q13002-1] A0A804HIH6 A0A804HKU0 G3XAD3 ENST00000684027.1 A0A804HI04 A0A804HHV9 ENST00000684518.1 H7BZX7 A0A804HL10 ENST00000358361.7 ENST00000369134 ENST00000683215.1 [Q13002-1] ENST00000683903.1 ENST00000684068.1 [Q13002-5] A0A804HKP5 ENST00000413795.5 [Q13002-2] ENST00000455610.5 ENST00000369138.5 [Q13002-5] A0A8D9PH75 ENST00000681975.1 ENST00000369137.8 F8WEZ8 D7RWZ8 Q13002 ENST00000682090.1 [Q13002-1] ENST00000682115.1 Q9BZ15 ENST00000683806.1 H7C2P5 A0A804HKS7 A0A0A0MRL4

GRIK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review