GRHL3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRHL3 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0008544Biological processepidermis development
GO_0061436Biological processestablishment of skin barrier
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0090103Biological processcochlea morphogenesis
GO_0090179Biological processplanar cell polarity pathway involved in neural tube closure
GO_0042060Biological processwound healing
GO_0001843Biological processneural tube closure
GO_0007417Biological processcentral nervous system development
GO_0061029Biological processeyelid development in camera-type eye
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0007398Biological processectoderm development
GO_0001736Biological processestablishment of planar polarity
GO_0007389Biological processpattern specification process
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRHL3
Protein nameGrainyhead like transcription factor 3
Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)
Grainyhead-like protein 3 homolog
SynonymsSOM
TFCP2L4
DescriptionFUNCTION: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes . xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm . No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity . .

AccessionsENST00000692334.1 [Q8TE85-4]
ENST00000528064
Q8TE85
ENST00000528064.6 [Q8TE85-4]
ENST00000461318.2
ENST00000350501.9 [Q8TE85-1]
ENST00000689444.1 [Q8TE85-3]
E9PLG9
E9PLT6
ENST00000690803.1 [Q8TE85-4]
ENST00000524724
ENST00000524724.6 [Q8TE85-3]
A0A8I5KUQ1
ENST00000356046.6 [Q8TE85-3]
ENST00000361548.9 [Q8TE85-5]
ENST00000236255.4 [Q8TE85-2]