GOPC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045176Biological processapical protein localization
GO_0006893Biological processGolgi to plasma membrane transport
GO_2000009Biological processnegative regulation of protein localization to cell surface
GO_0015031Biological processprotein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0010360Biological processnegative regulation of anion channel activity
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0000139Cellular componentGolgi membrane
GO_0014069Cellular componentpostsynaptic density
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0005737Cellular componentcytoplasm
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042802Molecular functionidentical protein binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0140313Molecular functionmolecular sequestering activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGOPC
Protein nameGolgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)
Golgi-associated PDZ and coiled-coil motif containing protein transcript variant 4
Golgi associated PDZ and coiled-coil motif containing (Golgi-associated PDZ and coiled-coil motif containing protein transcript variant 3)
SynonymsCAL
FIG
DescriptionFUNCTION: Plays a role in intracellular protein trafficking and degradation . May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor . May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR . Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes . .

AccessionsF5H1Y4
ENST00000368498.7 [Q9HD26-1]
Q9HD26
ENST00000535237.2
T1WFC1
ENST00000052569.10 [Q9HD26-2]