GLYR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0000786Cellular componentnucleosome
GO_0031491Molecular functionnucleosome binding
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0050661Molecular functionNADP binding
GO_0051287Molecular functionNAD binding
GO_0140463Molecular functionchromatin-protein adaptor activity
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameGLYR1
Protein nameCytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1)
Cytokine-like nuclear factor N-PAC (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Putative oxidoreductase GLYR1)
Glyoxylate reductase 1 homolog
SynonymsNDF
HIBDL
NP60
NPAC
DescriptionFUNCTION: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression . Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation . Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA . Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes . Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 . With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation . Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling . Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 . The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 . .

AccessionsK7EQB2
ENST00000587936.5
ENST00000588297.5
K7EK70
ENST00000591451.5 [Q49A26-3]
ENST00000587297.1
K7EPU6
ENST00000589389.5
ENST00000436648.9 [Q49A26-5]
K7EMM8
K7ELL0
ENST00000588732.5
ENST00000321919.14 [Q49A26-1]
Q49A26