Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 13 studies | 26% ± 10% | |
| endothelial cell | 12 studies | 26% ± 9% | |
| glutamatergic neuron | 8 studies | 36% ± 23% | |
| epithelial cell | 7 studies | 36% ± 12% | |
| macrophage | 7 studies | 25% ± 7% | |
| astrocyte | 7 studies | 28% ± 12% | |
| microglial cell | 6 studies | 23% ± 8% | |
| oligodendrocyte | 6 studies | 24% ± 7% | |
| adipocyte | 5 studies | 20% ± 3% | |
| GABAergic neuron | 5 studies | 38% ± 19% | |
| oligodendrocyte precursor cell | 5 studies | 28% ± 11% | |
| monocyte | 5 studies | 19% ± 2% | |
| goblet cell | 5 studies | 26% ± 11% | |
| neuron | 4 studies | 29% ± 11% | |
| myeloid cell | 4 studies | 22% ± 3% | |
| retinal rod cell | 4 studies | 19% ± 3% | |
| cardiac muscle cell | 4 studies | 26% ± 2% | |
| fibroblast | 4 studies | 20% ± 4% | |
| endothelial cell of lymphatic vessel | 4 studies | 20% ± 4% | |
| interneuron | 4 studies | 37% ± 23% | |
| classical monocyte | 3 studies | 26% ± 6% | |
| hematopoietic precursor cell | 3 studies | 19% ± 2% | |
| non-classical monocyte | 3 studies | 21% ± 4% | |
| retinal cone cell | 3 studies | 21% ± 3% | |
| lymphocyte | 3 studies | 22% ± 3% | |
| dendritic cell | 3 studies | 28% ± 7% | |
| abnormal cell | 3 studies | 24% ± 10% | |
| ependymal cell | 3 studies | 29% ± 12% | |
| enteroendocrine cell | 3 studies | 22% ± 5% | |
| basal cell | 3 studies | 29% ± 12% | |
| transit amplifying cell | 3 studies | 27% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 7981.49 | 1445 / 1445 | 100% | 63.77 | 183 / 183 |
| ovary | 100% | 5007.38 | 180 / 180 | 100% | 60.95 | 430 / 430 |
| prostate | 100% | 6722.36 | 245 / 245 | 100% | 91.77 | 502 / 502 |
| brain | 100% | 6061.39 | 2641 / 2642 | 100% | 86.27 | 705 / 705 |
| lung | 100% | 5881.84 | 578 / 578 | 100% | 62.52 | 1154 / 1155 |
| breast | 100% | 5615.76 | 459 / 459 | 100% | 94.13 | 1117 / 1118 |
| uterus | 100% | 5892.63 | 170 / 170 | 100% | 62.30 | 458 / 459 |
| kidney | 100% | 6185.00 | 89 / 89 | 100% | 65.84 | 899 / 901 |
| stomach | 100% | 6142.21 | 359 / 359 | 100% | 66.52 | 285 / 286 |
| thymus | 100% | 6695.74 | 653 / 653 | 99% | 77.17 | 601 / 605 |
| intestine | 100% | 7862.15 | 966 / 966 | 99% | 67.31 | 523 / 527 |
| skin | 100% | 6254.49 | 1809 / 1809 | 99% | 63.05 | 468 / 472 |
| pancreas | 100% | 3520.14 | 327 / 328 | 99% | 60.14 | 177 / 178 |
| bladder | 100% | 6965.52 | 21 / 21 | 99% | 52.74 | 499 / 504 |
| adrenal gland | 100% | 6625.28 | 258 / 258 | 98% | 58.99 | 226 / 230 |
| liver | 100% | 4020.54 | 226 / 226 | 98% | 40.52 | 397 / 406 |
| adipose | 100% | 5283.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5612.34 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 60.30 | 29 / 29 |
| muscle | 100% | 5448.86 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6748.62 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 59.38 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 22.99 | 1 / 1 |
| heart | 99% | 4833.93 | 851 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 43.07 | 78 / 80 |
| peripheral blood | 96% | 4502.32 | 896 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0140673 | Biological process | transcription elongation-coupled chromatin remodeling |
| GO_0045815 | Biological process | transcription initiation-coupled chromatin remodeling |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0000786 | Cellular component | nucleosome |
| GO_0031491 | Molecular function | nucleosome binding |
| GO_0035064 | Molecular function | methylated histone binding |
| GO_0003677 | Molecular function | DNA binding |
| GO_0050661 | Molecular function | NADP binding |
| GO_0051287 | Molecular function | NAD binding |
| GO_0140463 | Molecular function | chromatin-protein adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042393 | Molecular function | histone binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | GLYR1 |
| Protein name | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) Cytokine-like nuclear factor N-PAC (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Putative oxidoreductase GLYR1) Glyoxylate reductase 1 homolog |
| Synonyms | NDF HIBDL NP60 NPAC |
| Description | FUNCTION: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression . Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation . Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA . Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes . Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 . With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation . Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling . Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 . The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 . . |
| Accessions | K7EQB2 ENST00000587936.5 ENST00000588297.5 K7EK70 ENST00000591451.5 [Q49A26-3] ENST00000587297.1 K7EPU6 ENST00000589389.5 ENST00000436648.9 [Q49A26-5] K7EMM8 K7ELL0 ENST00000588732.5 ENST00000321919.14 [Q49A26-1] Q49A26 |